3,4-二羟基苯甲酸乙酯合成路线 （共 47 条）
反应条件
conc. HNO3; tetra-(n-butyl)ammonium iodide; potassium carbonate in water; acetic acid; acetone
参考文献
PFIZER INC.
Patent: EP1110953 A1, 2001 ;
反应条件
conc. HNO3; tetra-(n-butyl)ammonium iodide in acetic acid; acetone
参考文献
Pfizer Inc.
Patent: US5747498 A1, 1998 ;
US 5747498 A
反应条件
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating 2: acetic acid; nitric acid / 24 h / 20 °C View Scheme
参考文献
Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 11 p. 829 - 843
反应条件
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 4: 84 percent / 12 h / 165 - 170 °C 5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C View Scheme
参考文献
Molecules, , vol. 11, # 4 p. 286 - 297
反应条件
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating 2: acetic acid; nitric acid / 24 h / 20 °C 3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr 4: 84 percent / 12 h / 165 - 170 °C View Scheme
参考文献
Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 11 p. 829 - 843
反应条件
potassium carbonate; potassium iodide in acetone T=60°C; 19 h; Inert atmosphere;
参考文献
Shih, Kae-Shyang; Hsieh, Yu-Jung; Liu, Ching-Wei
Patent: US2010/267949 A1, 2010 ;
Location in patent: Page/Page column 6 ;
反应条件
potassium carbonate in acetonitrile 6 h; Reflux;
参考文献
Shenzhen Salubris Pharmaceuticals Co., Ltd.; Shanghai Institute of Pharmaceutical Industry; LI, Jianqi; ZHANG, Zixue; XIE, Peng; ZHANG, Qingwei
Patent: EP2592083 A1, 2013 ;
Location in patent: Paragraph 0258 ;
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in acetone 120 h; Heating;
参考文献
Knesl, Petr; Roeseling, Dirk; Jordis, Ulrich
Molecules, 2006 , vol. 11, # 4 p. 286 - 297
反应条件
potassium tert-butylate; tetrabutylammomium bromide in N,N-dimethyl-formamide T=30 - 40°C; 10 h;
参考文献
Zhang, Gengzhen; Zha, Linlin
Research on Chemical Intermediates, 2013 , vol. 39, # 6 p. 2303 - 2309
反应条件
potassium carbonate in acetone
参考文献
Zeneca Limited
Patent: US5821246 A1, 1998 ;
