3-氟-4-硝基苯酚合成路线

参考文献

Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.
Patent: US2003/236287 A1, 2003 ;
Location in patent: Page 40 ;
US 20030236287 A1

64-67-5硫酸二乙酯+

394-41-23-氟-4-硝基苯酚

28987-48-64-乙氧基-2-氟-1-硝基苯

参考文献

ALLERGAN, INC.; EHRING, George, R.; CHAO, Ellen; NG, Herman; TON, Hau; LI, Jia Chian; ADORANTE, Joseph, S.; GARST, Michael, E.; RIND, Howard, B.; HANSEN, Mark, R.; AVEY, JR., Alfred, A.; DOLBY, Lloyd, J.; ESFANDIARI, Shervin; MACKENZIE, Vivian, R.; MARSDEN, Jeremiah, A.; MUCHMORE, David, C.
Patent: WO2013/101911 A2, 2013 ;
Location in patent: Page/Page column 38 ;

394-41-23-氟-4-硝基苯酚

835621-07-3Regorafenib 盐酸盐

参考文献

BAYER HEALTHCARE LLC; WILHELM, Scott
Patent: WO2011/130728 A1, 2011 ;
WO 2011/130728 A1

394-41-23-氟-4-硝基苯酚

755037-03-7瑞格菲尼

参考文献

WO2011/130728 A1, ;
WO 2011/130728 A1

394-41-23-氟-4-硝基苯酚

757251-39-14-(4-氨基-3-氟苯氧基)-N-甲基吡啶-2-甲酰胺

参考文献

BAYER HEALTHCARE LLC; WILHELM, Scott
Patent: WO2011/130728 A1, 2011 ;
WO 2011/130728 A1

394-41-23-氟-4-硝基苯酚+

74-89-5甲胺

14703-79-83-(甲基氨基)-4-硝基苯酚

参考文献

SGX PHARMACEUTICALS, INC.
Patent: WO2008/51808 A2, 2008 ;
Location in patent: Page/Page column 83 ;
WO 2008/051808 A2

394-41-23-氟-4-硝基苯酚+

124-41-4甲醇钠

16292-95-83-甲氧基-4-硝基苯酚

参考文献

CELLZOME LIMITED; RAMSDEN, Nigel; MAJOR, Jeremy; MOREL, Adeline; SUNOSE, Mihiro; PITON, Nelly
Patent: WO2010/142766 A2, 2010 ;
Location in patent: Page/Page column 43-44 ;
WO 2010/142766 A2

67-56-1甲醇+

394-41-23-氟-4-硝基苯酚

16292-95-83-甲氧基-4-硝基苯酚

参考文献

PFIZER LIMITED
Patent: WO2009/144632 A1, 2009 ;
Location in patent: Page/Page column 77 ;

394-41-23-氟-4-硝基苯酚+

865-33-8甲醇钾

16292-95-83-甲氧基-4-硝基苯酚

参考文献

NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/80980 A1, 2004 ;
Location in patent: Page 135 ;
WO 2004/080980 A1

394-41-23-氟-4-硝基苯酚+

100-39-0溴化苄

221040-07-94-苄氧基-2-氟-1-硝基苯

参考文献

Hutchinson, Douglas K.; Rosenberg, Teresa; Klein, Larry L.; Bosse, Todd D.; Larson, Daniel P.; He, Wenping; Jiang, Wen W.; Kati, Warren M.; Kohlbrenner, William E.; Liu, Yaya; Masse, Sherie V.; Middleton, Tim; Molla, Akhteruzzaman; Montgomery, Debra A.; Beno, David W.A.; Stewart, Kent D.; Stoll, Vincent S.; Kempf, Dale J.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 3887 - 3890