5-氯-2-氟苯(甲)酰氯合成路线 （共 6 条）
反应条件
thionyl chloride T=85°C; 10 h;
参考文献
Zhang, Xuan; Sheng, Li; Hayakawa, Teruaki; Ueda, Mitsuru; Higashihara, Tomoya
Journal of Materials Chemistry A, 2013 , vol. 1, # 37 p. 11389 - 11396
反应条件
1: 1.) n-BuLi / 1.) hexane/THF, -70 deg C, 4 h, 2.) RT, 16 h 2: SOCl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Gschwend; Hamdan
Journal of Organic Chemistry, 1982 , vol. 47, # 19 p. 3652 - 3657
反应条件
1: KMnO4 2: SOCl2 View Scheme
参考文献
CIBA
Patent: DE922480 , 1955 ;
反应条件
ammonia in dichloromethane; water 0.5 h;
参考文献
US2007/112019 A1, ;
Page/Page column 9/2 ;
反应条件
1: pyridine
2: ammonia / ethanol / Heating
View Scheme
参考文献
Raboisson, Pierre; Lenz, Oliver; Lin, Tse-I; Surleraux, Dominique; Chakravarty, Sarvajit; Scholliers, Annick; Vermeiren, Katrien; Delouvroy, Frederic; Verbinnen, Thierry; Simmen, Kenneth
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1843 - 1849
反应条件
in dichloromethane
T=0 - 20°C; 3 h;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14370 A2, 2004 ;
Location in patent: Page/Page column 61 ;
WO 2004/014370 A2
