4-甲氧基-3-硝基三氟甲苯合成路线 （共 11 条）
参考文献
Imperial Chemical Industries PLC
Patent: US4388472 A1, 1983 ;
反应条件
sodium methylate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dimethyl sulfoxide; toluene
参考文献
EASTMAN CHEMICAL COMPANY
Patent: EP988276 B1, 2003 ;
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride in sulfolane T=180°C;
参考文献
Maggini, Michele; Passudetti, Margherita; Gonzales-Trueba, Guadalupe; Prato, Maurizio; Quintily, Ugo; Scorrano, Gianfranco
Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6406 - 6411
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
1: PCl5 / Einleiten von Chlor 2: anhydrous HF / 85 °C 3: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C 4: methanol. KOH View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
1: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C 2: methanol. KOH View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
1: anhydrous HF / 85 °C 2: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C 3: methanol. KOH View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
potassium fluoride; polymethylhydrosiloxane; palladium diacetate in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Rahaim Jr., Ronald J.; Maleczka Jr., Robert E.
Synthesis, 2006 , # 19 p. 3316 - 3340
反应条件
hydrogenchloride in water; isopropyl alcohol; toluene
参考文献
Imperial Chemical Industries PLC
Patent: US4388472 A1, 1983 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol; water T=20°C; P=760.051 Torr; 3.5 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 121 ;
EP 1403255 A1
