1-苄基-3-甲氧羰基-4-哌啶酮盐酸盐合成路线 (共 9 条)
反应条件
hydrogenchloride; potassium tert-butylate in toluene
参考文献
Busch, Frank R; Chiu, Charles K; Meltz, Clifford N; Post, Ronald J; Rose, Peter R
Patent: US2002/2283 A1, 2002 ;
反应条件
sodium methylate T=100°C; 3 h; in xylene or toluene; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 7 p. 1885 - 1892
反应条件
1: methanol / Heating 2: sodium methoxide / 3 h / 100 °C / in xylene or toluene View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 7 p. 1885 - 1892
反应条件
sulfuric acid in water 48 h; Ambient temperature;
参考文献
Unangst, Paul C.; Capiris, Thomas; Connor, David T.; Heffner, Thomas G.; MacKenzie, Robert G.; Miller, Steven R.; Pugsley, Thomas A.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 17 p. 2688 - 2693
反应条件
hydrogen; palladium on activated charcoal in acetic acid
参考文献
Lazar; Bernath
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 1885 - 1892
反应条件
hydrogen; triethylamine; palladium 10 on activated carbon in ethanol 24 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2004/2957 A1, 2004 ;
Location in patent: Page 44 ;
WO 2004/002957 A1
反应条件
ammonium hydroxide; sodium carbonate in ethanol
参考文献
Hoechst Aktiengesellschaft
Patent: US5556854 A1, 1996 ;
反应条件
1: 60 percent / NaOEt / ethanol / 12 h / 100 °C 2: 83 percent / H2, aq. HCl / 10percent Pd-C / methanol / 10 h / Heating View Scheme
参考文献
Lazar; Bernath
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 1885 - 1892
反应条件
1: 60 percent / H2SO4 / H2O / 48 h / Ambient temperature
2: H2 / 20percent Pd/C / methanol; tetrahydrofuran / 18 h / Ambient temperature
View Scheme
参考文献
Unangst, Paul C.; Capiris, Thomas; Connor, David T.; Heffner, Thomas G.; MacKenzie, Robert G.; Miller, Steven R.; Pugsley, Thomas A.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 17 p. 2688 - 2693