3,4-二羟基-5-甲氧基苯甲酸甲酯合成路线 （共 32 条）
反应条件
potassium carbonate in acetone T=80°C; 4 h; Heating / reflux;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 88 ;
反应条件
potassium carbonate in ethyl acetate; acetone
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
potassium carbonate in dichloromethane; N,N-dimethyl-formamide T=105°C; 6 h;
参考文献
Wu, Gang; Guo, Huan-Fang; Gao, Kun; Liu, Yi-Nan; Bastow, Kenneth F.; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Xie, Lan
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5272 - 5276
反应条件
potassium carbonate in N,N-dimethyl-formamide 4 h; Heating;
参考文献
Zhang, Wei-Ge; Zhao, Rui; Ren, Jian; Ren, Li-Xiang; Lin, Jin-Guang; Liu, Dai-Lin; Wu, Ying-Liang; Yao, Xin-Sheng
Archiv der Pharmazie, 2007 , vol. 340, # 5 p. 244 - 250
反应条件
1: K2CO3 / acetone 2: 62 percent / Br2; AcOH / 2 h / 20 °C 3: 90 percent / aq. KOH / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 9 p. 2131 - 2136
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in chloroform T=20°C; 24 h;
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: K2CO3 / acetone
2: 77 percent / HNO3 / 2 h / 0 - 5 °C
3: 34 percent / SnCl2*2H2O; aq. HCl / 0.5 h / Heating
View Scheme
参考文献
Chang, Junbiao; Chen, Rongfeng; Guo, Ruiyun; Dong, Chunhong; Zhao, Kang
Helvetica Chimica Acta, 2003 , vol. 86, # 6 p. 2239 - 2246
反应条件
1: 10.4 g / K2CO2 / dimethylformamide / 4 h / Heating
2: 89.3 percent / NaBH4; I2 / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Pettit; Singh
Canadian Journal of Chemistry, 1987 , vol. 65, # 10 p. 2390 - 2396
反应条件
1: methyl 5-methoxy-3,4-dihydroxybenzoate With potassium carbonate; potassium iodide in acetone
T=20°C; 0.5 h;
2: benzyl chloride in acetone
8 h; Reflux;
3: With ethanol; sodium hydroxide
Reflux;
参考文献
Universitat De Barcelona; Fundació Privada Institut de Recerca Biomèdica; Iproteos S.L.; Giralt Lledo', Ernest; Tarrago' Clua, Teresa; Prades Cosano, Roger; Royo Gracia, Soledad
Patent: EP2730571 A1, 2014 ;
Location in patent: Paragraph 0149; 0150 ;
反应条件
1: K2CO3 / dimethylformamide
2: aq. KOH
View Scheme
参考文献
Kang, Hak Hee; Rho, Ho Sik; Hwang, Jae Sung; Oh, Seong-Geon
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1085 - 1088
