3,4-二羟基-5-甲氧基苯甲酸甲酯合成路线 （共 32 条）
反应条件
Na2B4O7; sodium hydroxide in water
参考文献
Pettit; Singh
Canadian Journal of Chemistry, 1987 , vol. 65, # 10 p. 2390 - 2396
反应条件
sodium hydroxide; borax; dimethyl sulfate
参考文献
Tsumura Juntendo, Inc.
Patent: US4849448 A1, 1989 ;
反应条件
sodium hydroxide; borax; sulfuric acid; dimethyl sulfate in water
参考文献
ARIZONA BOARD OF REGENTS
Patent: EP276051 B1, 1991 ;
反应条件
sodium hydroxide; sulfuric acid; Na2B4O7 in water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
sodium hydroxide; B4H2O7(2-)*2Na(1+) in water T=20°C; 5 h;
参考文献
Wu, Gang; Guo, Huan-Fang; Gao, Kun; Liu, Yi-Nan; Bastow, Kenneth F.; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Xie, Lan
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5272 - 5276
参考文献
Hodgson, Jonathan M.; Morton, Lincoln W.; Puddey, Ian B.; Beilin, Lawrence J.; Croft, Kevin D.
Journal of Agricultural and Food Chemistry, 2000 , vol. 48, # 6 p. 2276 - 2280
反应条件
1: 92 percent / K2CO3 / diethyl ether; acetone / 20 °C 2: 80 percent aq. AcOH / 5 h / 108 °C View Scheme
参考文献
Jurd
Journal of the American Chemical Society, 1959 , vol. 81, p. 4606,4608
反应条件
manganese(IV) oxide; acetic acid in water 0.0166667 h; Title compound not separated from byproducts.;
参考文献
Kindler, Bernhard L. J.; Spiteller, Peter
Angewandte Chemie - International Edition, 2007 , vol. 46, # 42 p. 8076 - 8078
反应条件
1: 100 percent / sulfuric acid / 6 h / Heating 2: 98.5 percent / Amberlyst 15E / benzene / 18 h / Heating 3: potassium carbonate / dimethylformamide / 12 h / 70 °C 4: hydrochloric acid / methanol; H2O / 2 h / 20 °C View Scheme
参考文献
Hodgson, Jonathan M.; Morton, Lincoln W.; Puddey, Ian B.; Beilin, Lawrence J.; Croft, Kevin D.
Journal of Agricultural and Food Chemistry, 2000 , vol. 48, # 6 p. 2276 - 2280
反应条件
1: potassium carbonate / dimethylformamide / 12 h / 70 °C 2: hydrochloric acid / methanol; H2O / 2 h / 20 °C View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
