ALPHA-氧代-1-(苯基甲基)-5-[4-(三氟甲氧基)苯基]-1H-吲哚-3-乙酸合成路线 （共 7 条）
反应条件
1: With potassium hydroxide; water in tetrahydrofuran
T=20°C; 0.666667 h;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Wyeth
Patent: US2003/125371 A1, 2003 ;
反应条件
potassium hydroxide in acetone
T=20°C; 1 h;
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
反应条件
1.1: tBuOK / dimethylformamide / 0.5 h / 20 °C
1.2: 93 percent / dimethylformamide / 3 h / 20 °C
2.1: 80 percent / aq. K2CO3; Pd(OAc)2; Bu4NBr / dioxane / 36 h / 75 °C
3.1: tetrahydrofuran / 1 h / 20 °C
4.1: 3.35 g / tetrahydrofuran / 0.42 h / 20 °C
5.1: 90 percent / aq. KOH / acetone / 1 h / 20 °C
View Scheme
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
反应条件
1: 80 percent / aq. K2CO3; Pd(OAc)2; Bu4NBr / dioxane / 36 h / 75 °C
2: tetrahydrofuran / 1 h / 20 °C
3: 3.35 g / tetrahydrofuran / 0.42 h / 20 °C
4: 90 percent / aq. KOH / acetone / 1 h / 20 °C
View Scheme
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
反应条件
1.1: tBuOK / dimethylformamide / 0.5 h / 20 °C
1.2: 93 percent / dimethylformamide / 3 h / 20 °C
2.1: 80 percent / aq. K2CO3; Pd(OAc)2; Bu4NBr / dioxane / 36 h / 75 °C
3.1: tetrahydrofuran / 1 h / 20 °C
4.1: 3.35 g / tetrahydrofuran / 0.42 h / 20 °C
5.1: 90 percent / aq. KOH / acetone / 1 h / 20 °C
View Scheme
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
反应条件
1: tetrahydrofuran / 1 h / 20 °C
2: 3.35 g / tetrahydrofuran / 0.42 h / 20 °C
3: 90 percent / aq. KOH / acetone / 1 h / 20 °C
View Scheme
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
反应条件
1: 3.35 g / tetrahydrofuran / 0.42 h / 20 °C
2: 90 percent / aq. KOH / acetone / 1 h / 20 °C
View Scheme
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494
