1: 3-fluoropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78°C; 1 h; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C; 1 h; 3: With hydrogenchloride in tetrahydrofuran; water pH=5;
参考文献
MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS
Patent: WO2006/36015 A2, 2006 ;
Location in patent: Page/Page column 121-122 ;
WO 2006/036015 A2
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-40°C; 0.5 h; Cooling with acetone-dry ice; 2: 3-fluoropyridine in tetrahydrofuran; hexane T=-60°C; 0.5 h; 3: With hydrogenchloride in water pH=3; 1 h; Cooling with ice;
