Wise, Lawrence D.; Butler, Donald E.; DeWald, Horace A.; Lustgarten, David M.; Pattison, Ian C.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1807 - 1812
1: acetoacetic acid methyl ester With sodium hydride in toluene; mineral oil
T=20°C; 0.166667 h;
2: 2-fluoro-benzoyl chloride in toluene; mineral oil
Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BATT, Douglas, G.
Patent: WO2010/9069 A1, 2010 ;
Location in patent: Page/Page column 39 ;
WO 2010/009069 A1
