2-氨基-5-氟三氟甲苯合成路线 （共 10 条）
反应条件
hydrogen; palladium on activated carbon in toluene T=60°C; P=15001.5 Torr; 5 h;
参考文献
EP1524261 A1, ;
Page/Page column 7 ;
反应条件
potassium hydroxide; hydrogen fluoride in hexane; dichloromethane; water
反应条件
ammonium chloride; iron
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1972
反应条件
1: concentrated H2SO4; concentrated HNO3 2: iron; aqueous ammonium chloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1972
反应条件
bismuth; hydrogen fluoride in dichloromethane Yields of byproduct given;
参考文献
Journal of Fluorine Chemistry, , vol. 74, # 2 p. 251 - 254
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
hydrogenchloride T=0°C; Diazotization.Umsetzung mit NaBF4 und Erhitzen des entstandenen Diazonium-tetrafluoroborats;
参考文献
Finger; Reed
Journal of the American Chemical Society, 1944 , vol. 66, p. 1972
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating 4: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: With acetic acid; sodium nitrite in water; acetonitrile T=0°C; 0.333333 h; 2: With sulfur dioxide in water; acetonitrile 0.166667 h; 3: With copper dichloride in water; acetonitrile T=20°C;
参考文献
WYETH
Patent: WO2008/61016 A1, 2008 ;
Location in patent: Page/Page column 84 ;
反应条件
pyridine; phosphorus trichoride in toluene
12 h; Inert atmosphereReflux;
参考文献
Lee, Ill-Young; Gruber, Todd D.; Samuels, Amanda; Yun, Minhan; Nam, Bora; Kang, Minseo; Crowley, Kathryn; Winterroth, Benjamin; Boshoff, Helena I.; Barry III, Clifton E.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 114 - 126
