5-氨基-2-硝基三氟甲苯合成路线 （共 43 条）
参考文献
Whalley
Journal of the Chemical Society, 1949 , p. 3016,3019
反应条件
1: ethanol; concentrated H2SO4 / 0 - 10 °C / Erwaermen der Reaktionsloesung mit Kupferbronze 2: palladium / Hydrogenation 3: Bildung ueber die Diazonium-Verbindung 4: water; bromine 5: aq. NaOH solution View Scheme
参考文献
Jones
Journal of the American Chemical Society, 1947 , vol. 69, p. 2352
参考文献
Baker,J.W. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 93 - 95
参考文献
Baker,J.W. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 93 - 95
反应条件
Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuSO4 oder CuCl in wss. HCl in der Waerme;
参考文献
Journal of the Chemical Society, , p. 3016,3019
反应条件
1: acetic acid; sulfuric acid; aqueous sodium nitrite solution / Reagens 4: wss. Phosphinsaeure 2: Raney nickel; dioxane / 180 °C / 14710.2 Torr / Hydrogenation 3: aqueous HCl; sodium acetate; H2O / Diazotization View Scheme
参考文献
Pettit; Tatlow
Journal of the Chemical Society, 1954 , p. 1071,1073
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C; 3.75 h;
参考文献
Schragl, Katharina M.; Forsdahl, Guro; Gmeiner, Guenter; Enev, Valentin S.; Gaertner, Peter
Tetrahedron Letters, 2013 , vol. 54, # 18 p. 2239 - 2242
反应条件
thionyl chloride; isobutyramide
1.) from -20 to -10 deg C, 30 min, 2.) RT, 3 h; Yield given. Multistep reaction;
参考文献
Morris; Hughes; Glen; Taylor
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 447 - 455
反应条件
N-iodo-succinimide in tetrahydrofuran; methanol
参考文献
Lanter, James C.; Fiordeliso, James J.; Jiang, Weiqin; Allan, George F.; Lai, Muh-Tsann; Linton, Olivia; Hahn, Do Won; Lundeen, Scott G.; Sui, Zhihua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 123 - 126
反应条件
1: NIS; p-TsOH / methanol; tetrahydrofuran
2: pyridine / Heating
3: aq. NaOH / methanol
View Scheme
参考文献
Lanter, James C.; Fiordeliso, James J.; Jiang, Weiqin; Allan, George F.; Lai, Muh-Tsann; Linton, Olivia; Hahn, Do Won; Lundeen, Scott G.; Sui, Zhihua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 123 - 126
