5-氟-2-硝基三氟甲苯合成路线 （共 11 条）
反应条件
sulfuric acid; nitric acid 1) 30-35 deg C 2) 15 min, 60 deg C;
参考文献
Humm; Schneider
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 83 - 87
参考文献
Gen. Aniline Works
Patent: FR800343 , 1936 ;
Full Text Show Details
Gen. Aniline Works
Patent: US2086029 , 1935 ;
参考文献
Gen. Aniline Works
Patent: FR800343 , 1936 ;
Full Text Show Details
Gen. Aniline Works
Patent: US2086029 , 1935 ;
反应条件
ammonium chloride; iron
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1972
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
1: iron; aqueous ammonium chloride 2: aqueous HCl / 0 °C / Diazotization.Umsetzung mit NaBF4 und Erhitzen des entstandenen Diazonium-tetrafluoroborats View Scheme
参考文献
Finger; Reed
Journal of the American Chemical Society, 1944 , vol. 66, p. 1972
反应条件
ammonia in hexane; water; ethyl acetate
参考文献
Pfizer Inc.
Patent: US4728653 A1, 1988 ;
反应条件
1: 45 percent / Na2S*9H2O, S, NaOH / ethanol / Heating 2: 89 percent / Cl2, aq.AcOH / 10 °C View Scheme
参考文献
Humm; Schneider
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 83 - 87
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
2: dihydrogen peroxide; trifluoroacetic anhydride / dichloromethane; water / 3 h / Reflux; Inert atmosphere
View Scheme
参考文献
Payen, Olivier; Top, Siden; Vessires, Anne; Brule, Emilie; Lauzier, Agns; Plamont, Marie-Aude; McGlinchey, Michael J.; Mueller-Bunz, Helge; Jaouen, Gerard
Journal of Organometallic Chemistry, 2011 , vol. 696, # 5 p. 1049 - 1056
反应条件
1.1: NaH / dimethylformamide / 0.33 h / 20 °C
1.2: dimethylformamide / 3 h / 20 °C
2.1: 6.6 g / trifluoroacetic acid / CH2Cl2 / 18 h / Heating
3.1: 74 percent / SnCl2 / ethanol / 18 h / Heating
View Scheme
参考文献
Chiba, Jun; Iimura, Shin; Yoneda, Yoshiyuki; Watanabe, Toshiyuki; Muro, Fumito; Tsubokawa, Masao; Iigou, Yutaka; Satoh, Atsushi; Takayama, Gensuke; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1679 - 1693
