3-(3,4-二甲氧基苯基)-1-丙醇合成路线 （共 29 条）
反应条件
lithium aluminium tetrahydride
参考文献
Tschuksanowa et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959 , p. 2218,2223; engl. Ausg. S. 2114, 2117, 2118
反应条件
sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide
1.) THF, 1.5 h, 2.) THF, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Li, Shiming; Lundquist, Knut
Acta Chemica Scandinavica, 1995 , vol. 49, # 1 p. 64 - 67
反应条件
sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide
1.) THF, 1.5 h, 2.) THF, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Li, Shiming; Lundquist, Knut
Acta Chemica Scandinavica, 1995 , vol. 49, # 1 p. 64 - 67
反应条件
sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide
1.) THF, 1.5 h, 2.) THF, 1 h; Multistep reaction;
参考文献
Li, Shiming; Lundquist, Knut
Acta Chemica Scandinavica, 1995 , vol. 49, # 1 p. 64 - 67
反应条件
1: 83 percent / 4 Angstroem molecular sieves; pyridinium chlorochromate / CH2Cl2 / 1.5 h / 23 °C
2: piperidine*HCl / dioxane; H2O / 16 h / Heating
3: 2.35 g / NaBH4 / methanol / 2 h
4: CuCl2*H2O; (S)-p-tol-BINAP; t-BuONa / PMHS; i-PrOH / pentane; toluene; CH2Cl2 / 4.5 h / -20 °C
View Scheme
参考文献
Hughes, Gregory; Kimura, Masanari; Buchwald, Stephen L.
Journal of the American Chemical Society, 2003 , vol. 125, # 37 p. 11253 - 11258
反应条件
Montmorillonite K10; bis-[(trifluoroacetoxy)iodo]benzene in various solvent(s)
T=0 - 20°C; 2 h;
参考文献
Hamamoto, Hiromi; Hata, Kayoko; Nambu, Hisanori; Shiozaki, Yukiko; Tohma, Hirofumi; Kita, Yasuyuki
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2293 - 2295
反应条件
H4SiW12O40; bis-[(trifluoroacetoxy)iodo]benzene in acetonitrile
T=0 - 20°C; 1 h;
参考文献
Hata, Kayoko; Hamamoto, Hiromi; Shiozaki, Yukiko; Caemmerer, Simon B.; Kita, Yasuyuki
Tetrahedron, 2007 , vol. 63, # 19 p. 4052 - 4060
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=0°C; 2 h; Inert atmosphere;
参考文献
Cueva, Juan Pablo; Nichols, David E.
Synthesis, 2009 , # 5 p. 715 - 720
反应条件
bromine; triphenylphosphine in diethyl ether; cyclohexane; water; acetonitrile
参考文献
Solvay Pharmaceuticals GmbH
Patent: US5677297 A1, 1997 ;
US 5677297 A
