3-(3,4-二甲氧基苯基)-1-丙醇合成路线 （共 29 条）
反应条件
1: PBr3 / benzene 2: (i) Mg, Et2O, THF, (ii) /BRN= 1900390/ 3: aq. H3PO4, P2O5 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 9, p. 27 - 29
反应条件
1: PBr3 / benzene 2: (i) Mg, Et2O, THF, (ii) /BRN= 1900390/ View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 9, p. 27 - 29
反应条件
dimethylsulfide borane complex in tetrahydrofuran; diethyl ether
T=75°C; 1.5 h;
参考文献
Padwa; Brodney; Marino J.P.; Sheehan
Journal of Organic Chemistry, 1997 , vol. 62, # 1 p. 78 - 87
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
4 h; Heating;
参考文献
Bode; Doyle; Protopopova; Zhou
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9146 - 9155
反应条件
1: With platinum(IV) oxide; hydrogen bromide; hydrogen in methanol
T=20°C; P=760.051 Torr; 12 h;
2: With sodium hydroxide in water
chemoselective reaction;
参考文献
Fujii, Hideaki; Okada, Kayoko; Ishihara, Marina; Hanamura, Shinichi; Osa, Yumiko; Nemoto, Toru; Nagase, Hiroshi
Tetrahedron, 2009 , vol. 65, # 51 p. 10623 - 10630
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
T=25°C; 12 h;
2: With dihydrogen peroxide in sodium hydroxide
T=25°C; 2 h;
参考文献
Cruz, Adriana; Garduno, Leticia; Salazar, Maria; Martinez, Elizdath; Diaz, Francisco; Chamorro, German; Tamariz, Joaquin
Medicinal Chemistry Research, 2001 , vol. 10, # 9 p. 587 - 595
反应条件
hydrogen; palladium on activated charcoal in methanol
P=1810.02 Torr; 2 h;
参考文献
Enoki, Akio; Yajima, Yasuo; Gold, Michael H.
Phytochemistry (Elsevier), 1981 , vol. 20, # 6 p. 1543 - 1546
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Chemex Pharmaceuticals, Inc.
Patent: US4954659 A1, 1990 ;
反应条件
sodium tetrahydroborate; CoCl2.6H2O; diisopropylamine in ethanol
T=50°C; 24 h; chemoselective reaction;
参考文献
Jagdale, Arun R.; Paraskar, Abhimanyu S.; Sudalai, Arumugam
Synthesis, 2009 , # 4 p. 660 - 664
反应条件
1: H2 / Pd-C / acetic acid
2: LiAlH4 / diethyl ether
View Scheme
参考文献
Douglas,G.H. et al.
Journal of Medicinal Chemistry, 1966 , vol. 9, p. 27 - 29
