1,1-二苯基-2-丙炔-1-醇合成路线 (共 64 条)
参考文献
Hennion; Fleck
Journal of the American Chemical Society, 1955 , vol. 77, p. 3253,3257
反应条件
sodium hydroxide; tetrabutylammomium bromide in toluene
T=70°C; 1 h;
参考文献
Dehmlow, Eckehard V.; Shamout, Abdul Rahman
Liebigs Annalen der Chemie, 1982 , # 9 p. 1750 - 1752
反应条件
oxygen; copper(l) chloride
参考文献
Hartzler,H.D.
Journal of the American Chemical Society, 1961 , vol. 83, p. 4990 - 4996
反应条件
1: KOH; acetic acid anhydride; diethyl ether / 0 °C
2: Raney nickel; ethanol; benzene / Hydrogenation
View Scheme
参考文献
Cadiot; Willemart
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1949 , vol. 229, p. 130
Bulletin de la Societe Chimique de France, 1951 , p. 100,103
反应条件
hydroxylamine in water; isopropyl alcohol
T=140°C; Cope-type hydroamination; Microwave irradiationInert atmosphere; regioselective reaction;
参考文献
Moran, Joseph; Gorelsky, Serge I.; Dimitrijevic, Elena; Lebrun, Marie-Eve; Bedard, Anne-Catherine; Seguin, Catherine; Beauchemin, Andre M.
Journal of the American Chemical Society, 2008 , vol. 130, # 52 p. 17893 - 17906
反应条件
hydroxylamine in water; isopropyl alcohol
T=140°C;
参考文献
Loiseau, Francis; Beauchemin, Andre M.
Organic Syntheses, 2013 , vol. 90, p. 87 - 95
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 1 h / -78 °C
2.1: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 1 h / 80 °C
View Scheme
参考文献
Mothe, Srinivasa Reddy; Lauw, Sherman Jun Liang; Kothandaraman, Prasath; Chan, Philip Wai Hong
Journal of Organic Chemistry, 2012 , vol. 77, # 16 p. 6937 - 6947
反应条件
toluene-4-sulfonic acid in toluene
6 h; Heating;
参考文献
Pozzo, Jean-Luc; Samat, Andre; Guglielmetti, Robert; Dubest, Roger; Aubard, Jean
Helvetica Chimica Acta, 1997 , vol. 80, # 3 p. 725 - 738
反应条件
hypophosphorous ether in benzene
9 h; Heating;
参考文献
Belakhov, V. V.; Yudelevich, V. I.; Komarov, E. V.; Ionin, B. I.; Myasnikova, L. G.; Roshchin, A. A.
J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 1 p. 39 - 44,33 - 37
反应条件
1: pyridine
2: dioxane
3: palladium/CaCO3; dioxane / Hydrogenation
View Scheme
参考文献
Huggill; Rose
Journal of the Chemical Society, 1950 , p. 335,339