2,6-二氟-4-硝基苯甲醚合成路线 （共 15 条）
反应条件
in methanol T=35°C; ΔH(excit.), ΔS(excit.); var. temp.; Rate constantKineticsThermodynamic data;
参考文献
Cervera; Marquet; Martin
Tetrahedron, 1996 , vol. 52, # 7 p. 2557 - 2564
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
反应条件
1: 99 percent / H2 / 10 percent Pd/C / ethyl acetate 2: 64 percent / I2, aq. NaHCO3 / Ambient temperature 3: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h 4: 83 percent / dimethylformamide / 22 h / 120 - 140 °C View Scheme
参考文献
Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
反应条件
1: platinum; methanol / Hydrogenation
2: aqueous H2SO4; aqueous CuSO4-solution; xylene / Diazotization
View Scheme
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
