2-氟-4-硝基苯甲酸甲酯合成路线 （共 12 条）
反应条件
sulfuric acid Reflux;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; DAMANN, Nils; LESCH, Bernhard; BAHRENBERG, Gregor; SAUNDERS, Derek John; STOCKHAUSEN, Hannelore; KIM, Yong-Soo; KIM, Myeong-Seop; LEE, Jeewoo
Patent: WO2013/68467 A1, 2013 ;
Location in patent: Page/Page column 57; 59; 60; 61 ;
反应条件
in methanol; diethyl ether; toluene T=20°C; 1.5 h;
参考文献
CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2008/51547 A1, 2008 ;
Location in patent: Page/Page column 533 ;
WO 2008/051547 A1
反应条件
in diethyl ether T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/14900 A1, 2004 ;
Location in patent: Page 52 ;
WO 2004/014900 A1
反应条件
tetramethyl-ammonium fluoride in dimethyl sulfoxide T=60°C; 1 h;
参考文献
Boechat, Nubia; Clark, James H.
Journal of the Chemical Society, Chemical Communications, 1993 , # 11 p. 921 - 922
反应条件
nitric acid Yield given. Multistep reaction;
参考文献
Soundararajan, N.; Platz, Matthew S.
Journal of Organic Chemistry, 1990 , vol. 55, # 7 p. 2034 - 2044
反应条件
1: 70 percent / Na2Cr2O7; H2SO4 / 90 °C 2: 93 percent / H2SO4 View Scheme
参考文献
Das, Jagattaran; Rao, C.V. Laxman; Sastry; Roshaiah; Sankar, P. Gowri; Khadeer, Abdul; Kumar, M. Sitaram; Mallik, Arundhuti; Selvakumar; Iqbal, Javed; Trehan, Sanjay
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 2 p. 337 - 343
参考文献
Goldstein; Urvater
Helvetica Chimica Acta, 1951 , vol. 34, p. 1350,1354
反应条件
methanol; sodium tetrahydroborate T=23°C; 4 h;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; DAMANN, Nils; LESCH, Bernhard; BAHRENBERG, Gregor; SAUNDERS, Derek John; STOCKHAUSEN, Hannelore; KIM, Yong-Soo; KIM, Myeong-Seop; LEE, Jeewoo
Patent: WO2013/68467 A1, 2013 ;
Location in patent: Page/Page column 65; 66 ;
反应条件
hydrazine in ethanol 14 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/37814 A1, 2004 ;
Location in patent: Page 166-167 ;
WO 2004/037814 A1
反应条件
hydrogen; nickel in tetrahydrofuran; methanol T=20°C;
参考文献
Takahashi, Keiji; Hashimoto, Noriaki; Nakama, Chisato; Kamata, Kenji; Sasaki, Kaori; Yoshimoto, Riki; Ohyama, Sumika; Hosaka, Hideka; Maruki, Hiroko; Nagata, Yasufumi; Eiki, Jun-ichi; Nishimura, Teruyuki
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 19 p. 7042 - 7051
