3-(2,6-二氯苯基)-5-甲基异恶唑-4-羧酸合成路线 （共 10 条）
反应条件
1: 2,6-di-(chloro)-benzaldehyde With hydroxylammonium sulfate in methanol T=20 - 40°C; 1 h; 2: With chlorine; sodium carbonate; triethylamine in methanol T=0 - 20°C; pH=~ 9.5; 24 h; Inert atmosphere; 3: acetoacetic acid methyl ester With sodium carbonate in methanol pH=~ 7 - 7.5;
参考文献
VARDHMAN CHEMTECH LIMITED; GUJRAL, Rajinder Singh; JAIN, Suyog
Patent: WO2012/164355 A1, 2012 ;
Location in patent: Page/Page column 10 ;
反应条件
sodium hydroxide in methanol
参考文献
Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Schaefer, Verlyn G.; Falls, Douglas H.; Kaszubska, Wiweka; Colins, Christine A.; Sham, Hing L.; Liu, Gang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1201 - 1204
反应条件
1: NaOMe / methanol / 20 °C 2: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
potassium hydroxide in ethanol
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
1: (i) NH2OH, (ii) Cl2, CHCl3, (iii) /BRN= 506727/, MeOH 2: aq. KOH / ethanol View Scheme
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
1.1: chlorine / methanol / 0 - 5 °C 2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 2.2: 2 h / 0 - 20 °C / pH 9 3.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux View Scheme
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
phosphorus pentachloride T=45°C; 1 h;
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
1: phosphorus pentachloride / toluene 2: ammonium hydroxide / ethyl acetate / pH 2 - 8 View Scheme
参考文献
VARDHMAN CHEMTECH LIMITED; GUJRAL, Rajinder Singh; JAIN, Suyog
Patent: WO2012/164355 A1, 2012 ;
反应条件
1: 92 percent / LAH / tetrahydrofuran / 12 h / 20 °C 2: 91 percent / SOCl2 / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Epple, Robert; Russo, Ross; Azimioara, Mihai; Cow, Christopher; Xie, Yongping; Wang, Xing; Wityak, John; Karanewsky, Don; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4376 - 4380
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 12 h;
参考文献
Epple, Robert; Russo, Ross; Azimioara, Mihai; Cow, Christopher; Xie, Yongping; Wang, Xing; Wityak, John; Karanewsky, Don; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4376 - 4380
