4-(1,4-二甲基-1-乙基)戊基酚合成路线 （共 26 条）
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=-78 - 20°C; 3 h; 2: With water in diethyl ether
参考文献
BEIERSDORF AF,
Patent: US2007/189984 A1, 2007 ;
Location in patent: Page/Page column 12-13 ;
反应条件
triphenyl-arsane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in N,N-dimethyl-formamide T=20°C; Stille coupling; 2 h;
参考文献
Wada, Akimori; Fukunaga, Kouki; Ito, Masayoshi; Mizuguchi, Yukari; Nakagawa, Kimie; Okano, Toshio
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 14 p. 3931 - 3942
反应条件
triphenyl-arsane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in N,N-dimethyl-formamide T=20°C; Stille coupling reaction; 2 h;
参考文献
Wada, Akimori; Ieki, Yasuhiro; Nakamura, Saeko; Ito, Masayoshi
Synthesis, 2005 , # 10 art. no. F00105SS, p. 1581 - 1588
反应条件
triphenyl-arsane; bis(dibenzylideneacetone)-palladium(0) in 1-methyl-pyrrolidin-2-one T=50°C; Substitution; Stille reaction; 5 h;
参考文献
Dominguez, Beatriz; Pazos, Yolanda; De Lera, Angel R.
Journal of Organic Chemistry, 2000 , vol. 65, # 19 p. 5917 - 5925
反应条件
1: 91 percent / NaH / diethyl ether / 20 °C 2: LiAlH4 / diethyl ether / -78 °C View Scheme
参考文献
McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D.
Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410
反应条件
1: With n-butyllithium; potassium tert-butylate in hexane T=25°C; 1 h; 2: With sodium hydroxide; fluorodimethoxyborane*Et2O in hexane T=25°C; 1 h; Further stages.;
参考文献
Rauchschwalbe, Guenter; Zellner, Armin; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 20 p. 3903 - 3909
反应条件
lithium aluminium tetrahydride in diethyl ether T=-78°C;
参考文献
Lai, Wai Cheu; McLean, Neville; Gansmueller, Axel; Verhoeven, Michiel A.; Antonioli, Gian Carlo; Carravetta, Marina; Duma, Luminita; Bovee-Geurts, Petra H. M.; Johannessen, Ole G.; De Groot, Huub J. M.; Lugtenburg, Johan; Emsley, Lyndon; Brown, Steven P.; Brown, Richard C. D.; DeGrip, Willem J.; Levitt, Malcolm H.
Journal of the American Chemical Society, 2006 , vol. 128, # 12 p. 3878 - 3879
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2 h; Inert atmosphere; 2: With water; sodium sulfate in tetrahydrofuran Inert atmosphere;
参考文献
Sadikoglou, Eldem; Magoulas, George; Theodoropoulou, Christina; Athanassopoulos, Constantinos M.; Giannopoulou, Efstathia; Theodorakopoulou, Olga; Drainas, Denis; Papaioannou, Dionysios; Papadimitriou, Evangelia
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 8 p. 3175 - 3187
反应条件
1: 85 percent / tetrahydrofuran / -78 °C 2: 91 percent / NaH / diethyl ether / 20 °C 3: LiAlH4 / diethyl ether / -78 °C View Scheme
参考文献
Lai, Wai Cheu; McLean, Neville; Gansmueller, Axel; Verhoeven, Michiel A.; Antonioli, Gian Carlo; Carravetta, Marina; Duma, Luminita; Bovee-Geurts, Petra H. M.; Johannessen, Ole G.; De Groot, Huub J. M.; Lugtenburg, Johan; Emsley, Lyndon; Brown, Steven P.; Brown, Richard C. D.; DeGrip, Willem J.; Levitt, Malcolm H.
Journal of the American Chemical Society, 2006 , vol. 128, # 12 p. 3878 - 3879
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Boehm, Marcus F.; McClurg, Michael R.; Pathirana, Charles; Mangelsdorf, David; White, Steven K.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 408 - 414
