4-羟基-4'-硝基联苯合成路线 （共 12 条）
反应条件
sodium salt of phosphorous acid; palladium on activated charcoal in water; isopropyl alcohol T=20°C; Suzuki-Miyaura cross-coupling; 8 h;
参考文献
Kitamura, Yoshiaki; Sakurai, Ai; Udzu, Takahiro; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao
Tetrahedron, 2007 , vol. 63, # 43 p. 10596 - 10602
反应条件
1: With potassium carbonate in ethanol; water T=80°C; 24 h; 2: With hydrogenchloride; water in ethanol
参考文献
Butschies, Martin; Sauer, Sven; Kessler, Elena; Siehl, Hans-Ullrich; Claasen, Birgit; Fischer, Peter; Frey, Wolfgang; Laschat, Sabine
ChemPhysChem, 2010 , vol. 11, # 17 p. 3752 - 3765
反应条件
hydrogen bromide; acetic acid T=120°C;
参考文献
WYETH
Patent: WO2005/30702 A1, 2005 ;
Location in patent: Page/Page column 63-64 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethylene glycol dimethyl ether T=80°C; 16 h;
参考文献
Todd, Matthew H.; Balasubramanian, Shankar; Abell, Chris
Tetrahedron Letters, 1997 , vol. 38, # 38 p. 6781 - 6784
反应条件
1: T=140°C; Diels-Alder reaction; 2 h; 2: With potassium carbonate in methanol 0.166667 h; Further stages.;
参考文献
Ashburn, Bradley O.; Carter, Rich G.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 2 p. 255 - 257
反应条件
hydrogenchloride Diazotization.nachf. Behandeln mit verd. Schwefelsaeure und Zersetzen des Diazoniumsulfats mit Wasserdampf;
参考文献
You; Brezzell; Das; Hooberman; Sinsheimer
Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure, 1994 , vol. 320, # 1-2 p. 45 - 58
参考文献
Novak, Michael; Poturalski, Matthew J.; Johnson, Whitney L.; Jones, Matthew P.; Wang, Yueting; Glover, Stephen A.
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3778 - 3785
反应条件
1: 100 percent / triethylamine / 1.5 h / 20 °C 2: 96 percent / hydrogen; diethylamine / palladium on carbon / methanol / 57 h / 20 °C View Scheme
参考文献
Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao
Tetrahedron, 2007 , vol. 63, # 5 p. 1270 - 1280
反应条件
1: 93 percent / H2 / Pd/C / ethyl acetate / 18 h / 20 °C / 1861.73 Torr 2: 58 percent / DIEA / tetrahydrofuran / 12 h / 20 °C View Scheme
参考文献
Dickerson, Tobin J.; Tremblay, Martin R.; Hoffman, Timothy Z.; Ruiz, Diana I.; Janda, Kim D.
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15395 - 15401
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Hanaoka, Kenjiro; Kikuchi, Kazuya; Terai, Takuya; Komatsu, Toru; Nagano, Tetsuo
Chemistry - A European Journal, 2008 , vol. 14, # 3 p. 987 - 995
