2-甲基-3-氧代丁酸叔丁酯合成路线 （共 12 条）
反应条件
trifluoroacetic acid T=20°C; 24 h;
参考文献
Anwar, Muhammad; Cowley, Andrew R.; Moloney, Mark G.
Tetrahedron Asymmetry, 2010 , vol. 21, # 13-14 p. 1758 - 1770
反应条件
sulfuric acid; acetic anhydride 1.) ice-cooling, 3 h, 2.) 0 deg C, 12 h;
参考文献
Sato, Masayuki; Ogasawara, Hiromichi; Oi, Keiichi; Kato, Tetsuzo
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 6 p. 1896 - 1901
反应条件
1: NH2OH / methanol / 0 °C 2: NaBH3CN / acetic acid; tetrahydrofuran / 0 °C 3: H2 / Raneyi-Ni / methanol 4: cc. HCl View Scheme
参考文献
Chiba; Ishizawa; Sakaki; Kaneko
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 11 p. 4672-4675
反应条件
1: acetoacetic acid tert-butyl ester With sodium hydride in tetrahydrofuran
T=20°C; 3 h;
2: methyl iodide in tetrahydrofuran
T=80°C; 12 h;
参考文献
Osako, Takao; Panichakul, Duanghathai; Uozumi, Yasuhiro
Organic Letters, 2012 , vol. 14, # 1 p. 194 - 197
反应条件
1: propionic acid tert-butyl ester With n-butyllithium; diisopropylamine in diethyl ether
T=-78°C; 1 h; Inert atmosphere;
2: N,O-dimethylacetohydroxamic acid in diethyl ether
T=-78 - 20°C; Inert atmosphere;
3: With hydrogenchloride in diethyl ether; water
T=20°C; Inert atmosphere;
参考文献
Palomo, Claudio; Oiarbide, Mikel; Garcia, Jesus M.; Banuelos, Patricia; Odriozola, Jose M.; Razkin, Jesus; Linden, Anthony
Organic Letters, 2008 , vol. 10, # 13 p. 2637 - 2640
反应条件
1: acetoacetic acid tert-butyl ester With sodium hydride in tetrahydrofuran; mineral oil
T=20°C; Inert atmosphere;
2: methyl halide in tetrahydrofuran; mineral oil
T=20 - 40°C; Inert atmosphere;
参考文献
Hashimoto, Takuya; Naganawa, Yuki; Maruoka, Keiji
Journal of the American Chemical Society, 2009 , vol. 131, p. 6614 - 6617
反应条件
2,4,6-trichloro-1,3,5-triazine; N,N-dimethyl-aniline in acetonitrile
T=0 - 20°C; Inert atmosphere;
参考文献
Bertogg, Andreas; Hintermann, Lukas; Huber, Dominique P.; Perseghini, Mauro; Sanna, Maria; Togni, Antonio
Helvetica Chimica Acta, 2012 , vol. 95, # 3 p. 353 - 403
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in toluene
Heating;
参考文献
Ribeiro, Rodrigo S.; De Souza, Rodrigo O. M. A.; Vasconcellos, Mario L. A. A.; Oliveira, Bianca L.; Ferreira, Leonardo C.; Aguiar, Lucia C. S.
Synthesis, 2007 , # 1 p. 61 - 64
反应条件
1: potassium hydroxide / water / 24 h / 20 °C / Inert atmosphere
2: 2,4,6-trichloro-1,3,5-triazine; N,N-dimethyl-aniline / acetonitrile / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Bertogg, Andreas; Hintermann, Lukas; Huber, Dominique P.; Perseghini, Mauro; Sanna, Maria; Togni, Antonio
Helvetica Chimica Acta, 2012 , vol. 95, # 3 p. 353 - 403
反应条件
1: benzene / 4 h / Heating
2: Pd(PPh3)4-PPh3 / tetrahydrofuran / 45 h / Ambient temperature
View Scheme
参考文献
Hiroi; Abe
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 616 - 621
