6-溴-2-氯-4-甲基喹啉合成路线 （共 10 条）
反应条件
trichlorophosphate Heating;
参考文献
Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942
反应条件
in trichlorophosphate
参考文献
Burroughs Wellcome Co.
Patent: US4587341 A1, 1986 ;
反应条件
in trichlorophosphate
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP96214 B1, 1991 ;
反应条件
1: acetonitrile / 1 h / 200 °C / Microwave irradiation 2: sulfuric acid / 2 h / 95 °C 3: trichlorophosphate / 80 °C View Scheme
参考文献
Wlodarczyk, Nicolas; Simenel, Catherine; Delepierre, Muriel; Barale, Jean-Christophe; Janin, Yves L.
Synthesis, 2011 , # 6 art. no. T51110SS, p. 934 - 942
反应条件
1: 25.6 percent / conc. H2SO4 / 120 °C 2: 97 percent / POCl3 / Heating View Scheme
参考文献
Wlodarczyk, Nicolas; Simenel, Catherine; Delepierre, Muriel; Barale, Jean-Christophe; Janin, Yves L.
Synthesis, 2011 , # 6 art. no. T51110SS, p. 934 - 942
反应条件
T=70°C; 12 h; sealed tube;
参考文献
STEIN, Philip; DAINES, Robert; SPROUS, Dennis; O'GRADY, Harold
Patent: WO2010/132615 A1, 2010 ;
Location in patent: Page/Page column 139 ;
WO 2010/132615 A1
反应条件
dimethyl amine in ethanol; water
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP96214 B1, 1991 ;
反应条件
dimethyl amine in ethanol
参考文献
Burroughs Wellcome Co.
Patent: US4587341 A1, 1986 ;
参考文献
Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942
反应条件
1: 74 percent / ethanol / Heating
2: 1) n-BuLi / 1) THF, hexane, -78 deg C, 5 min, 2) to -20 deg C
View Scheme
参考文献
Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942
