2-氨基-5-氟苯甲酸乙酯合成路线 （共 7 条）
反应条件
1: 1.) Na2CO3, 2.) 25percent NH4OH / 1.) 80 deg C, 18 h, 2.) H2O, EtOH, 2 h 2: 67 percent / Na / ethanol; diethyl ether / 2 h / Heating View Scheme
参考文献
Boes, M.; Jenck, F.; Martin, J. R.; Moreau, J. L.; Mutel, V.; et al.
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 3 p. 253 - 262
反应条件
2: oxalyl dichloride View Scheme
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emmerson; CAMPBELL, Una; HANANIA, Taleen, G.; SHAO, Liming
Patent: WO2013/119895 A1, 2013 ;
反应条件
2: oxalyl dichloride 3: palladium on activated charcoal View Scheme
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emmerson; CAMPBELL, Una; HANANIA, Taleen, G.; SHAO, Liming
Patent: WO2013/119895 A1, 2013 ;
反应条件
sulfuric acid in ethanol; toluene
参考文献
Andrews,III, Clarence Webster; Freeman, George Andrew; Hopkins, Andrew Lee
Patent: US2003/69271 A1, 2003 ;
反应条件
ethanol; platinum
Hydrogenation;
参考文献
Fosdick; Blackwell
Journal of the American Chemical Society, 1944 , vol. 66, p. 1165
反应条件
1: thionyl chloride
3: platinum; ethanol / Hydrogenation
View Scheme
参考文献
Fosdick; Blackwell
Journal of the American Chemical Society, 1944 , vol. 66, p. 1165
反应条件
2: platinum; ethanol / Hydrogenation
View Scheme
参考文献
Fosdick; Blackwell
Journal of the American Chemical Society, 1944 , vol. 66, p. 1165
