5-羟基-2-[[3-(三氟甲基)苯基]氨基]苯甲酸合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
1.5 h;
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
反应条件
1: 49.8 percent / K2CO3 / Cu powder / 2 h / 160 °C
2: 96 percent / H2 / 10percent Pd/C / methanol / 1.5 h
View Scheme
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
反应条件
1: 87 percent / NaOH
2: 49.8 percent / K2CO3 / Cu powder / 2 h / 160 °C
3: 96 percent / H2 / 10percent Pd/C / methanol / 1.5 h
View Scheme
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
反应条件
1: 97 percent / H2 / Pt
2: 1) NaNO2
3: 87 percent / NaOH
4: 49.8 percent / K2CO3 / Cu powder / 2 h / 160 °C
5: 96 percent / H2 / 10percent Pd/C / methanol / 1.5 h
View Scheme
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
反应条件
1: 1) NaNO2
2: 87 percent / NaOH
3: 49.8 percent / K2CO3 / Cu powder / 2 h / 160 °C
4: 96 percent / H2 / 10percent Pd/C / methanol / 1.5 h
View Scheme
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
反应条件
1: (i) NaOEt, (ii) aq. NaOH
2: K2CO3, CuBr2, N-ethylmorpholine / bis-(2-methoxy-ethyl) ether
3: H2 / Pd-C
View Scheme
参考文献
Bowman,R.E. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 1 - 4
反应条件
1: K2CO3, CuBr2, N-ethylmorpholine / bis-(2-methoxy-ethyl) ether
2: H2 / Pd-C
View Scheme
参考文献
Bowman,R.E. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 1 - 4
