2-甲基-3-硝基苯甲酰氯合成路线 （共 13 条）
参考文献
Journal of Chemical Research, , # 6 p. 373 - 376
反应条件
1: benzene; pyridine 2: Raney nickel; ethanol / Hydrieren des Reaktionsprodukts an Raney-Nickel in Aethanol View Scheme
参考文献
Sorkin; Kraehenbuehl; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 65,74
反应条件
1: NaBH4 / tetrahydrofuran 2: SOCl2, pyridine View Scheme
参考文献
Namil, A.; Benoit-Guyod, M.; Leclerc, G.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 973 - 982
反应条件
1: NaBH4 / tetrahydrofuran 2: SOCl2, pyridine View Scheme
参考文献
Namil, A.; Benoit-Guyod, M.; Leclerc, G.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 973 - 982
反应条件
sodium tetrahydroborate in tetrahydrofuran
参考文献
Sorkin; Kraehenbuehl; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 65,74
反应条件
thionyl chloride
T=60°C; 24 h;
参考文献
Leze, Marie-Pierre; Palusczak, Anja; Hartmann, Rolf W.; Le Borgne, Marc
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4713 - 4715
反应条件
1: aqueous sulfuric acid / 150 °C
2: thionyl chloride
View Scheme
参考文献
Sorkin; Kraehenbuehl; Erlenmeyer
Helvetica Chimica Acta, 1948 , vol. 31, p. 65,74
反应条件
1: absolute nitric acid / 0 °C
2: PCl5
View Scheme
参考文献
van Scherpenzeel
Recueil des Travaux Chimiques des Pays-Bas, 1901 , vol. 20, p. 169
反应条件
1: 1.) Mg, CCl4 / 1.) EtOH, ether, reflux, 3 h, 2.) EtOH, ether, reflux, 10 min.
2: conc. H2SO4 / aq. acetic acid / 4 h / Heating
View Scheme
参考文献
Binder; Hromatka; Noe; Hillebrand; Veit; Blum
Archiv der Pharmazie, 1980 , vol. 313, # 7 p. 587 - 602
反应条件
1: pyridine; 4-(N,N-dimethlyamino)pyridine / 0.25 h / 60 °C / Microwave irradiation; Inert atmosphere
2: toluene-4-sulfonic acid / para-xylene / 18 h / 140 °C / Inert atmosphere
3: 10 palladium on activated carbon; hydrogen / methanol; ethanol; ethyl acetate / 3 h / 20 °C
View Scheme
参考文献
Keurulainen, Leena; Salin, Olli; Siiskonen, Antti; Kern, Jan Marco; Alvesalo, Joni; Kiuru, Paula; Maass, Matthias; Yli-Kauhaluoma, Jari; Vuorela, Pia
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7664 - 7674
