(1-甲基-1H-咪唑-5-基)甲醇合成路线 （共 36 条）
反应条件
manganese(IV) oxide in chloroform 23 h; Heating;
参考文献
Zarghi; Ebrahimabadi; Hassanzadeh; Heydari; Shafiee
Bollettino Chimico Farmaceutico, 2003 , vol. 142, # 6 p. 251 - 254
反应条件
1: 71 percent / MnO2 / CHCl3 / 48 h / Heating 2: methanol; H2O / 20 °C 3: 16.3 g / NaBH4 / methanol; H2O View Scheme
参考文献
Collman, James P.; Zhong, Min; Costanzo, Simona; Zhang, Chi
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8252 - 8256
参考文献
Journal of the American Chemical Society, , vol. 71, p. 2444,2447
反应条件
1.1: SOCl2 / CHCl3 / 1 h / Heating
1.2: HNO3; H2SO4; water / 2 h / 20 °C
1.3: 60 percent / water / propan-2-ol / 24 h / Heating
2.1: 80 percent / MnO2 / CHCl3 / 0.5 h / Heating
View Scheme
参考文献
Shafiee, Abbas; Rastkary, Noushin; Jorjani, Masoumeh; Shafaghi, Bijan
Archiv der Pharmazie (Weinheim, Germany), 2002 , vol. 335, # 2 p. 69 - 76
反应条件
thionyl chloride in 1,2-dichloro-ethane
T=20°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/66174 A1, 2006 ;
Location in patent: Page/Page column 99 ;
WO 2006/066174 A1
反应条件
phosphorus tribromide in dichloromethane
T=0 - 20°C;
参考文献
CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita
Patent: WO2010/132999 A1, 2010 ;
Location in patent: Page/Page column 136 ;
