2-乙酰基戊-4-烯酸甲酯合成路线 （共 19 条）
反应条件
1.1: polymer-supported selenium bromide resin / tetrahydrofuran / 3 h / 20 °C 1.2: NaI; MeI / dimethylformamide / 18 h / 75 °C 2.1: 74 percent / DBU / benzene / 12 h / 60 °C View Scheme
参考文献
Tang; Huang, Xian; Xu, Wei-Ming
Tetrahedron, 2004 , vol. 60, # 44 p. 9963 - 9969
反应条件
1: aq. NaOH / 20 °C / Saponification 2: aq. H2SO4 / Heating View Scheme
参考文献
Storcken, Roy P. M.; Panella, Lavinia; Van Delft, Floris L.; Kaptein, Bernard; Broxterman, Quirinus B.; Schoemaker, Hans E.; Rutjes, Floris P. J. T.
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 1-2 p. 161 - 164
参考文献
Goorbergh, J. A. M. van den; Gen, A. van der
Recueil: Journal of the Royal Netherlands Chemical Society, 1984 , vol. 103, # 3 p. 90 - 96
反应条件
1: in acetonitrile
T=20°C;
2: With triethylamine in hexane; ethyl acetate
T=20°C; 0.5 h;
参考文献
Zhang, Yang; Raines, Andrew J.; Flowers II, Robert A.
Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6267 - 6272
反应条件
1: acetoacetic acid methyl ester With sodium hydride in tetrahydrofuran
T=0°C; 0.333333 h;
2: 2-propenylsulfonyl chloride With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=25°C; 0.5 h; regioselective reaction;
参考文献
Rao Volla, Chandra M.; Dubbaka, Srinivas Reddy; Vogel, Pierre
Tetrahedron, 2009 , vol. 65, # 2 p. 504 - 511
反应条件
ceric tetrabutylammonium nitrate in acetonitrile
4 h;
参考文献
Zhang, Yang; Raines, Andrew J.; Flowers II, Robert A.
Organic Letters, 2003 , vol. 5, # 13 p. 2363 - 2365
反应条件
copper; Cu(II) perchlorate in tetrahydrofuran
8 h; Heating;
参考文献
Baruah, Jubaraj B.; Samuelson, Ashoka G.
Journal of Organometallic Chemistry, 1989 , vol. 361, p. C57 - C60
反应条件
1-methyl-piperidine; [Pt(PPh3)4]
T=100°C; 5 h;
参考文献
Zhang, Shi-Wei; Mitsudo, Take-aki; Kondo, Teruyuki; Watanabe, Yoshihisa
Journal of Organometallic Chemistry, 1995 , vol. 485, # 1-2 p. 55 - 62
反应条件
tetrakis(triphenylphosphine) palladium(0); triphenylphosphine in tetrahydrofuran
T=65°C; 7 h; Yield given. Yields of byproduct given;
参考文献
Lu, Xiyan; Jiang, Xiaohui; Tao, Xiaochun
Journal of Organometallic Chemistry, 1988 , vol. 344, p. 109 - 118
反应条件
1.1: 1.29 g / Amberlyst H-15; molecular sieves 4 Angstroem / pentane / 48 h
2.1: CTAN / acetonitrile / 20 °C
2.2: 5 percent / Et3N / hexane; ethyl acetate / 0.5 h / 20 °C
View Scheme
参考文献
Zhang, Yang; Raines, Andrew J.; Flowers II, Robert A.
Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6267 - 6272
