4-(吗啉-4-羰基)苯基硼酸合成路线 （共 2 条）
反应条件
1: With bis[2-(N,N-dimethylamino)ethyl] ether; isopropylmagnesium chloride in tetrahydrofuran T=15°C; 2: With boric acid trimethyl ester in tetrahydrofuran 0.666667 h; 3: With hydrogenchloride; water in tetrahydrofuran T=20°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PURANDARE, Ashok, Vinayak; BATT, Douglas, G.; LIU, Qingjie; JOHNSON, Walter, L.; MASTALERZ, Harold; ZHANG, Guifen; ZIMMERMANN, Kurt
Patent: WO2010/80474 A1, 2010 ;
Location in patent: Page/Page column 172 ;
WO 2010/080474 A1
反应条件
tetrahydroxydiboron; chloro(2-dicyclohexylphosphino-2',4',6'-triisoporpyl-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)] palladium (II); potassium acetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in ethanol T=80°C; 1.5 h; Inert atmosphere;
参考文献
Molander, Gary A.; Cavalcanti, Livia N.; Garcia-Garcia, Carolina
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6427 - 6439
