(R)-1-(1-萘基)乙胺合成路线 （共 75 条）
反应条件
D-(+)-camphoric acid
参考文献
Mathad, Vijayavitthal T.; Shinde, Gorakshanath B.; Ippar, Sharad S.; Niphade, Navnath C.; Panchangam, Raghavendra K.; Vankawala, Pravinchandra J.
Synthetic Communications, 2011 , vol. 41, # 3 p. 341 - 346
反应条件
1: NaH / dimethylformamide / 1.) 0 deg C, 1 h, 2.) ambient temp., 5 h 2: (S)-(-)-2-amino-3-methyl-1,1-diphenylbutanol*borane / tetrahydrofuran / 24 h / 30 °C View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
CF3COOH in dichloromethane To a soln. of complex in CH2Cl2 was added CF3CO2H, the mixt. was stirred for 10 min (N2 atm.); evapd., extd. with H2O, NaBF4 was added;; ppt. was filtered, recrystd. from CH2Cl2-hexane;;
参考文献
Merrifield, James H.; Strouse, Charles E.; Gladysz, J. A.
Organometallics, 1982 , vol. 1, p. 1204 - 1211
反应条件
Candida antarctica lipase B T=60°C; Title compound not separated from byproducts;
参考文献
Skupinska, Krystyna A.; McEachern, Ernest J.; Baird, Ian R.; Skerlj, Renato T.; Bridger, Gary J.
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3546 - 3551
反应条件
1: ammonia / water; toluene 2: potassium hydroxide / dimethyl sulfoxide / 20 h / 150 - 160 °C View Scheme
参考文献
Mathad, Vijayavitthal T.; Shinde, Gorakshanath B.; Ippar, Sharad S.; Niphade, Navnath C.; Panchangam, Raghavendra K.; Vankawala, Pravinchandra J.
Synthetic Communications, 2011 , vol. 41, # 3 p. 341 - 346
反应条件
1.1: hydroxylamine hydrochloride / water; methanol / 25 °C 2.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 3.2: 18 h / 20 °C 4.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 18 h / 20 °C 3.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) -100 deg C View Scheme
参考文献
Gawley, Robert E.; Rein, Kathleen; Chemburkar, Sanjay
Journal of Organic Chemistry, 1989 , vol. 54, # 13 p. 3002 - 3004
反应条件
sodium hydroxide; toluene-4-sulfonic acid 1) aq. EtOH, 20 h reflux; 2) benzene, 3 h reflux; Yield given. Multistep reaction;
参考文献
Pirkle, William H.; Adams, Paul E.
Journal of Organic Chemistry, 1980 , vol. 45, # 21 p. 4111 - 4117
反应条件
sodium hydroxide; toluene-4-sulfonic acid 1) aq. EtOH, 30 h, 110 deg C, 4 kbar; 2) benzene, 2 h, reflux; Yield given. Multistep reaction;
参考文献
Pirkle, William H.; Adams, Paul E.
Journal of Organic Chemistry, 1980 , vol. 45, # 21 p. 4111 - 4117
