R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
1: With [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; potassium tert-butylate; 2-amino-2-methyl-propan-1-ol in isopropyl alcohol T=50°C; 2 h; Molecular sieve; 2: With hydrogenchloride in methanol optical yield given as percent eediastereoselective reaction;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Tetrahedron Letters, 2011 , vol. 52, # 7 p. 789 - 791
反应条件
1: (-)-(S)-alpha-ethyl-2-oxo-1-pyrrolidineacet-N-(+)-(R)-(1-phenylethyl)-amide With sulfonic acid type-ion exchange resin; water in toluene 6 h; not specified; Heating / reflux; 2: methanol With sulfonic acid type-ion exchange resin in water; toluene T=60°C; 3 h;
参考文献
ZACH SYSTEM S.P.A.
Patent: WO2008/12268 A1, 2008 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: With ammonium cerium (IV) nitrate in methanol; water T=0°C; 6 h; 2: With sodium hydroxide in water
参考文献
Zhang, Xumu
Patent: US2004/147762 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
1: With hydrogenchloride; methanol; water T=80°C; 15 h; 2: With water; sodium hydroxide
参考文献
Postech Academy-Industry Foundation
Patent: US7592488 B2, 2009 ;
Location in patent: Page/Page column 19-20 ;
反应条件
1: With C10H18BNO in tetrahydrofuran T=20°C; 24 h; 2: With borane-THF in tetrahydrofuran 24 h; Reflux; optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Pakulski, Marcin M.; Mahato, Sanjit K.; Bosiak, Mariusz J.; Krzeminski, Marek P.; Zaidlewicz, Marek
Tetrahedron Asymmetry, 2012 , vol. 23, # 9 p. 716 - 721
反应条件
1: With [((R)-tol-binap)RuCl2(DMF)x]; ammonia; ammonium formate in methanol T=85°C; Leuckart-Wallach reaction; 20 h; 2: With hydrogenchloride in ethanol 1 h; Heating; Title compound not separated from byproducts;
参考文献
Nieto, Sonia; Dragna, Justin M.; Anslyn, Eric V.
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 227 - 232
反应条件
sodium tetrahydroborate; (S)-valinol; zirconium tetrachloride 1) THF, r.t., 2) THF, r.t.; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Sakurai, Yoshiki; Shimizu, Koji; Ito, Koichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1859 - 1863
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=25°C; 0.5 h; Inert atmosphere;
参考文献
Cano, Rafael; Ramon, Diego J.; Yus, Miguel
Journal of Organic Chemistry, 2011 , vol. 76, # 14 p. 5547 - 5557
反应条件
hexacarbonyl molybdenum in water; acetonitrile T=85°C; 1 h;
参考文献
Atobe, Masakazu; Yamazaki, Naoki; Kibayashi, Chihiro
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5595 - 5607
反应条件
Ni T=110°C; 1 h; Inert atmosphere; Reagent/catalyst;
参考文献
Geukens, Inge; Plessers, Eva; Seo, Jin Won; De Vos, Dirk E.
European Journal of Inorganic Chemistry, 2013 , # 14 p. 2623 - 2628
