N-苄氧羰基-L-谷氨酸γ-叔丁酯合成路线 （共 13 条）
反应条件
phosphate buffer; Bacillus subtilis esterase in methanol; hexane T=37°C; 48 h;
参考文献
Barbayianni, Efrosini; Fotakopoulou, Irene; Schmidt, Marlen; Constantinou-Kokotou, Violetta; Bornscheuer, Uwe T.; Kokotos, George
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8730 - 8733
反应条件
sodium hydroxide in ethanol
参考文献
Chevallet, Pierre; Garrouste, Patrick; Malawska, Barbara; Martinez, Jean
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7409 - 7412
反应条件
phosphate buffer; Bacillus subtilis esterase BS2 in methanol; hexane T=37°C; pH=7.4; 3 h; Product distribution; Further Variations:Reagentsreaction times; enzyme/substrate ratios;
参考文献
Fotakopoulou, Irene; Barbayianni, Efrosini; Constantinou-Kokotou, Violetta; Bornscheuer, Uwe T.; Kokotos, George
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 782 - 786
反应条件
1: 91 percent / benzyltriethylammonium chloride, K2CO3 / N,N-dimethyl-acetamide / 24 h / 55 °C 2: 82 percent / 1 N NaOH / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 46 p. 7409 - 7412
反应条件
1: 91 percent / TsOH / toluene / Heating 2: 95 percent / triethylamine, 4-dimethylamino-pyridine / CH2Cl2; 2-methyl-propan-2-ol / 4 h / Ambient temperature 3: NaOH / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 49 p. 6859 - 6860
参考文献
Justus Liebigs Annalen der Chemie, , vol. 673, p. 196 - 207
反应条件
ethanol; diethylamine
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 941 - 953
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Kobayashi, Kazuya; Oishi, Shinya; Kobayashi, Yuka; Ohno, Hiroaki; Tsutsumi, Hiroko; Hata, Yoji; Fujii, Nobutaka
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 8 p. 2651 - 2655
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; 24 h;
参考文献
Betschmann, Patrick; Sahli, Stefan; Diederich, Francois; Obst, Ulrike; Gramlich, Volker
Helvetica Chimica Acta, 2002 , vol. 85, # 5 p. 1210 - 1245
反应条件
dicyclohexyl-carbodiimide in ethyl acetate
参考文献
Hofmann,K. et al.
Journal of the American Chemical Society, 1965 , vol. 87, p. 611 - 619
