2,6-二氯-4-甲基烟酰胺合成路线 （共 5 条）
反应条件
sulfuric acid T=98°C; 6 h;
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
反应条件
1: 98 percent / POCl3 / 6 h / 120 °C 2: 93 percent / aq. H2SO4 / 6 h / 98 °C View Scheme
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
反应条件
1: NaOH, Br2 / Heating 2: various solvent(s) View Scheme
参考文献
Proudfoot; Hargrave; Kapadia; Patel; Grozinger; McNeil; Cullen; Cardozo; Tong; Kelly; Rose; David; Mauldin; Fuchs; Vitous; Hoermann; Klunder; Raghavan; Skiles; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4830 - 4838
反应条件
sulfuric acid; water; sodium nitrite T=20 - 60°C; 7.25 h;
参考文献
Wang, Yamin; Bullock, William H.; Chen, Libing
Patent: US6677352 B1, 2004 ;
Location in patent: Page/Page column 46 ;
反应条件
sodium hydroxide; bromine T=70 - 75°C; 1 h;
参考文献
Grozinger; Fuchs; Hargrave; Mauldin; Vitous; Campbell; Adams
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 259 - 263
