1: 2-(methanesulphonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 0.5 h; 2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde hydrochloride With water in tetrahydrofuran T=20°C; 4 h; 3: With sodium tris(acetoxy)borohydride in tetrahydrofuran

1: in acetonitrile 2 h; Reflux; 2: With water; sodium hydroxide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water 0.5 h; Product distribution / selectivity;