2-乙酰氨基-1-硝基-3,5,6-三氟苯合成路线 （共 3 条）
反应条件
sulfuric acid; nitric acid; acetic acid
参考文献
Yu, Walter; Dener, Jeffrey M.; Dickman, Daniel A.; Grothaus, Paul; Ling, Yun; Liu, Liang; Havel, Chris; Malesky, Kimberly; Mahajan, Tania; O'Brian, Colin; Shelton, Emma J.; Sperandio, David; Tong, Zhiwei; Yee, Robert; Mordenti, Joyce J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4053 - 4058
反应条件
1: 90 percent / Et3N / tetrahydrofuran / -20 - 20 °C
2: 50 percent / AcOH; H2SO4; HNO3
View Scheme
参考文献
Yu, Walter; Dener, Jeffrey M.; Dickman, Daniel A.; Grothaus, Paul; Ling, Yun; Liu, Liang; Havel, Chris; Malesky, Kimberly; Mahajan, Tania; O'Brian, Colin; Shelton, Emma J.; Sperandio, David; Tong, Zhiwei; Yee, Robert; Mordenti, Joyce J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4053 - 4058
反应条件
ammonia in methanol
T=120°C;
参考文献
Montgomery,J.A.; Hewson,K.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 737 - 740
