1: With iodine; magnesium in tetrahydrofuran Metallation; 0.25 h; Heating; 2: With sulfur in tetrahydrofuran Addition; 3 h; 3: in tetrahydrofuran T=20°C; Reduction; 0.5 h; Further stages.;
参考文献
Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840
1: With trifluoromethylsulfonic anhydride; (MeO2CH2CH2)2SO in dichloromethane T=-35 - 20°C; 2: With triethylamine in tetrahydrofuran T=20°C; 12 h; 3: With potassium tert-butylate in tetrahydrofuran T=-78°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Becht, Jean-Michel; Wagner, Alain; Mioskowski, Charles
Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5758 - 5761