17Alpha-羟基妊娠烯醇酮 合成路线 （共 34 条）
反应条件
1: 82 percent / hydrogen peroxide, potasium hydroxide / methanol; H2O 2: 55 percent / p-toluenesulfonic acid monohydrate / benzene / 4 h / Heating 3: lithium aluninium hydride / tetrahydrofuran / 2 h / Heating 4: sulfuric acid / methanol; H2O / 1 h / Heating View Scheme
参考文献
Kasal, Alexander; Pokora, Jenny; Zajicek, Jaroslav
反应条件
1: lithium aluninium hydride / tetrahydrofuran / 2 h / Heating 2: sulfuric acid / methanol; H2O / 1 h / Heating View Scheme
参考文献
Kasal, Alexander; Pokora, Jenny; Zajicek, Jaroslav
反应条件
1: 55 percent / p-toluenesulfonic acid monohydrate / benzene / 4 h / Heating 2: lithium aluninium hydride / tetrahydrofuran / 2 h / Heating 3: sulfuric acid / methanol; H2O / 1 h / Heating View Scheme
参考文献
Kasal, Alexander; Pokora, Jenny; Zajicek, Jaroslav
参考文献
Cutler et al.
反应条件
ammonia anschliessend mit Acetanhydrid und nachfolgend mit LiAlH4 und dann mit Peroxybenzoesaeure;
参考文献
Betancor, Carmen; Francisco, Cosme G.; Freire, Raimundo; Suarez, Ernesto
3517-42-8 [17-(2-乙酰氧基乙酰基)-17-羟基-10,13-二甲基-1,2,3,4,7,8,9,11,12,14,15,16-十二氢环戊烯并[a]菲-3-基]乙酸酯
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反应条件
反应条件
diethyl ether; methylmagnesium bromide; toluene Erhitzen des vom Aether befreiten Reaktionsgemisches und Behandeln einer Loesung des nach der Hydrolyse erhaltenen Reaktionsprodukts in Dioxan mit wss. Perjodsaeure;
参考文献
Fuchs; Reichstein
17975-91-6 1-[(3S,8R,9S,10R,13S,14S,16S,17R)-3,17-二羟基-16-碘-10,13-二甲基-1,2,3,4,7,8,9,11,12,14,15,16-十二氢环戊烯并[a]菲-17-基]乙酮
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反应条件
反应条件
Lindlar's catalyst; ethanol Hydrogenation;
参考文献
Farbw.Hoechst
反应条件
potassium tert-butylate; oxygen; phosphorous acid trimethyl ester 1) tBuOH, DMF; 2) acetic acid, THF, 1 h, ice-cooling; 40 h, room temp.; Yield given. Multistep reaction;
参考文献
Biancini, Bruno; Caciagli, Valerio; Centini, Felice; Eletti-Bianchi, Giancarlo; Re, Luciano
反应条件
potassium tert-butylate; oxygen; phosphorous acid trimethyl ester 1) tBuOH, DMF, -25 deg C, 3.5 h; 2) acetic acid, THF, 1 h, ice-cooling; 40 h, room temp.; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Biancini, Bruno; Caciagli, Valerio; Centini, Felice; Eletti-Bianchi, Giancarlo; Re, Luciano
反应条件
(i) Ac2O, Py, (ii) KOH, aq. MeOH; Multistep reaction;
参考文献
Gardner,J.N. et al.
