1-哌啶-1-基环己烷甲腈合成路线 （共 34 条）
反应条件
magnesium 1) ether, reflux, 1 h; 2) ether, reflux, 5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sindelar, Karel; Dobrovsky, Karel; Krejci, Ivan; Polivka, Zdenek
Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 5 p. 894 - 902
参考文献
Koetz; Merkel
Journal fuer Praktische Chemie (Leipzig), 1926 , vol. <2> 113, p. 74
反应条件
lithium aluminium tetrahydride; sulfuric acid in tetrahydrofuran; diethyl ether T=0 - 50°C; Reflux;
参考文献
McClure, Kelly J.; Maher, Michael; Wu, Nancy; Chaplan, Sandra R.; Eckert III, William A.; Lee, Dong H.; Wickenden, Alan D.; Hermann, Michelle; Allison, Brett; Hawryluk, Natalie; Breitenbucher, J. Guy; Grice, Cheryl A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5197 - 5201
参考文献
Allen and Hanburys Limited
Patent: US3975443 A1, 1976 ;
反应条件
aluminium hydride in tetrahydrofuran 20 h; Ambient temperature;
参考文献
Costa, Brian R. de; He, Xiao-shu; Linders, Joannes T.M.; Dominguez, Celia; Gu, Zi Qiang; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2311 - 2320
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Welvart
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1951 , vol. 233, p. 1121
反应条件
magnesium 1.) ether, RT, 2.) ether, reflux, 12 h; Multistep reaction;
参考文献
Ilagouma, AT; Maurice, T; Duterte-Boucher, D; Coderc, E; Vignon, J; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 377 - 385
反应条件
1: bromobenzene With iodine; magnesium in tetrahydrofuran; diethyl ether 2: 1-piperidin-1-yl-cyclohexanecarbonitrile in tetrahydrofuran; diethyl ether Reflux;
参考文献
Ahmadi, Abbas; Solati, Jalal; Hajikhani, Ramin; Pakzad, Sara
Asian Journal of Chemistry, 2011 , vol. 23, # 12 p. 5429 - 5432
参考文献
Ahmadi, Abbas; Solati, Jalal; Hajikhani, Ramin; Onagh, Masoud; Javadi, Mojdeh
Arzneimittel-Forschung/Drug Research, 2010 , vol. 60, # 8 p. 492 - 496
参考文献
Koetz; Merkel
Journal fuer Praktische Chemie (Leipzig), 1926 , vol. <2> 113, p. 74
