potassium permanganate; water in dichloromethane T=20°C; 0.25 h;

2-but-3'-en-1'-ylpyridine; ozone in dichloromethane T=-78°C; Inert atmosphere;

lithium carbonate; lithium bromide in dimethyl sulfoxide T=140 - 150°C; 60 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Fe(bpmen)(OTf)2; dihydrogen peroxide; acetic acid in acetonitrile T=20°C; Concentration;

Nitrous oxide in benzene T=250°C; P=38002.6 - 53203.6 Torr; 12 h;

1: With ozone in methanol; dichloromethane T=-70°C; 2: With dimethylsulfide T=-70 - 20°C; Inert atmosphere;

lead(IV) acetate in benzene 2.5 h; Heating;

in ethanol 288 h; Cephalosporium aphidicola IMI 68689;

1: 88 percent / triethylamine / dimethylformamide / 24 h / 95 °C 2: 96 percent / TiCl4 / CH2Cl2 / 1.5 h / -78 °C 3: 90 percent / p-toluenesulfonic acid / benzene / 2 h / Heating 4: 81 percent / TiCl4 / CH2Cl2 5: 71 percent / NaNH2 / benzene 6: 1.) O3; 2.) Zn/CH3COOH / 1.) -78 deg C, 30 min; 2.) room temperature overnight. 7: 73 percent / HCl / acetic acid / 21 h / Ambient temperature 8: 81 percent / SiO2 / CHCl3 / 27 h / 60 °C View Scheme

1: 88 percent / triethylamine / dimethylformamide / 24 h / 95 °C 2: 96 percent / TiCl4 / CH2Cl2 / 1.5 h / -78 °C 3: 90 percent / p-toluenesulfonic acid / benzene / 2 h / Heating 4: 81 percent / TiCl4 / CH2Cl2 5: 71 percent / NaNH2 / benzene 6: 1.) O3; 2.) Zn/CH3COOH / 1.) -78 deg C, 30 min; 2.) room temperature overnight. 7: 73 percent / HCl / acetic acid / 21 h / Ambient temperature 8: Al2O3 / hexane / 24 h / 60 °C View Scheme