3,4-二氟苯胺合成路线

参考文献

Societe de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6815546 B2, 2004 ;

参考文献

El-Abadelah, Mustafa M.; Nazer, Musa Z.; El-Abadla, Naser S.; Meier, Herbert
Heterocycles, 1995 , vol. 41, # 10 p. 2203 - 2220

3863-11-43,4-二氟苯胺

458-11-73’,4’-二氟乙酰苯胺

参考文献

Societe de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6815546 B2, 2004 ;

3863-11-43,4-二氟苯胺

458-11-73’,4’-二氟乙酰苯胺+

76179-41-4

参考文献

Eli Lilly and Company
Patent: US4264600 A1, 1981 ;

75-36-5乙酰氯+

3863-11-43,4-二氟苯胺

458-11-73’,4’-二氟乙酰苯胺

参考文献

Walker, Michael A.; Johnson, Timothy; Ma, Zhuping; Zhang, Yunhui; Banville, Jacques; Remillard, Roger; Plamondon, Serge; Pendri, Annapurna; Wong, Henry; Smith, Daniel; Torri, Albert; Samanta, Himadri; Lin, Zeyu; Deminie, Carol; Terry, Brian; Krystal, Mark; Meanwell, Nicholas
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5818 - 5821

3863-11-43,4-二氟苯胺

1366297-24-6+

458-11-73’,4’-二氟乙酰苯胺

参考文献

Blackburn, Anthony; Bowles, Daniel M.; Curran, Timothy T.; Kim, Hui
Synthetic Communications, 2012 , vol. 42, # 12 p. 1855 - 1863

321-14-25-氯代水杨酸+

3863-11-43,4-二氟苯胺

634186-48-4

参考文献

Lee, Ill-Young; Gruber, Todd D.; Samuels, Amanda; Yun, Minhan; Nam, Bora; Kang, Minseo; Crowley, Kathryn; Winterroth, Benjamin; Boshoff, Helena I.; Barry III, Clifton E.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 114 - 126

105-56-6氰乙酸乙酯+

3863-11-43,4-二氟苯胺

541519-41-9

参考文献

TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2009/136663 A1, 2009 ;
Location in patent: Page/Page column 216 ;
WO 2009/136663 A1

372-09-8氰乙酸+

3863-11-43,4-二氟苯胺

541519-41-9

参考文献

Hazeldine, Stuart; Pachaiyappan, Boobalan; Steinbergs, Nora; Nowotarski, Shannon; Hanson, Allison S.; Casero, Robert A.; Woster, Patrick M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7378 - 7391