反应条件
1.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C 2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.17 h / -78 °C 2.2: 0.58 h / -78 °C 3.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 5 h / 20 °C 4.1: potassium hydroxide / tert-butyl alcohol / 70 °C View Scheme
参考文献
SANOFI-AVENTIS; CHOI-SLEDESKI, Yong-Mi; GARDNER, Charles, J.; LIANG, Guyan; POLI, Gregory, B.; SHUM, Patrick, Wai-Kwok; STOKLOSA, Gregory, T.; ZHAO, Zhicheng
Patent: WO2011/22449 A1, 2011 ;
WO 2011/022449 A1