1-(4-硝基苯基)-2-哌啶酮合成路线 （共 10 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 20°C; 2: With potassium tert-butylate in tetrahydrofuran T=0 - 20°C;
参考文献
Pinto, Donald J.P.; Han, Wei; Hu, Zilun; Qiao, Jennifer
Patent: US2003/232804 A1, 2003 ;
Location in patent: Page 102 ;
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=100°C;
参考文献
Pinto, Donald J. P.; Orwat, Michael J.; Koch, Stephanie; Rossi, Karen A.; Alexander, Richard S.; Smallwood, Angela; Wong, Paneras C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; He, Kan; Xin, Baomin; Wexler, Ruth R.; Lam, Patrick Y. S.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 22 p. 5339 - 5356
反应条件
potassium tert-butylate in tetrahydrofuran T=5 - 20°C; 2.5 h; Inert atmosphere;
参考文献
Jiang, Jian'An; Ji, Yafei
Synthetic Communications, 2013 , vol. 43, # 1 p. 72 - 79
反应条件
1: triethylamine / tetrahydrofuran / 5 h / 5 - 20 °C / |Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere View Scheme
参考文献
Jiang, Jian'An; Ji, Yafei
Synthetic Communications, 2013 , vol. 43, # 1 p. 72 - 79
反应条件
1: triethylamine / tetrahydrofuran / 5 h / 5 - 20 °C / |Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere View Scheme
参考文献
Jiang, Jian'An; Ji, Yafei
Synthetic Communications, 2013 , vol. 43, # 1 p. 72 - 79
反应条件
1.1: phosphorus pentachloride / chloroform / |Reflux 2.1: 1 h / |Reflux 3.1: water; Na2S*9H2O / ethanol / 4 h / 50 °C 4.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 5.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 6.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 6.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1: 1-(4-nitrophenyl)piperidin-2-one With phosphorus pentachloride in chloroform 2 h; Heating; 2: morpholine T=130°C; 1 h; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 22 p. 5339 - 5356
反应条件
1: phosphorus pentachloride / chloroform / |Reflux 2: 1 h / |Reflux View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1: phosphorus pentachloride / chloroform / |Reflux 2: 1 h / |Reflux 3: water; Na2S*9H2O / ethanol / 4 h / 50 °C 4: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 5: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere View Scheme
参考文献
Jiang, Jian'An; Ji, Yafei
Synthetic Communications, 2013 , vol. 43, # 1 p. 72 - 79
反应条件
phosphorus pentachloride in chlorobenzene
T=25 - 55°C;
参考文献
Shapiro, Rafael; Rossano, Lucius T.; Mudryk, Boguslaw M.; Cuniere, Nicolas; Oberholzer, Matthew; Zhang, Huiping; Chen, Bang-Chi
Patent: US2006/69258 A1, 2006 ;
Location in patent: Page/Page column 12-13 ;
