1: With N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 20°C; 2: With potassium tert-butylate in tetrahydrofuran T=0 - 20°C;

potassium tert-butylate in N,N-dimethyl-formamide T=100°C;

potassium tert-butylate in tetrahydrofuran T=5 - 20°C; 2.5 h; Inert atmosphere;

1: triethylamine / tetrahydrofuran / 5 h / 5 - 20 °C / |Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere View Scheme

1: triethylamine / tetrahydrofuran / 5 h / 5 - 20 °C / |Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere View Scheme

1.1: phosphorus pentachloride / chloroform / |Reflux 2.1: 1 h / |Reflux 3.1: water; Na2S*9H2O / ethanol / 4 h / 50 °C 4.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 5.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 6.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 6.2: 0 - 20 °C View Scheme

1: 1-(4-nitrophenyl)piperidin-2-one With phosphorus pentachloride in chloroform 2 h; Heating; 2: morpholine T=130°C; 1 h; Further stages.;

1: phosphorus pentachloride / chloroform / |Reflux 2: 1 h / |Reflux View Scheme

1: phosphorus pentachloride / chloroform / |Reflux 2: 1 h / |Reflux 3: water; Na2S*9H2O / ethanol / 4 h / 50 °C 4: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 5: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere View Scheme

phosphorus pentachloride in chlorobenzene T=25 - 55°C;