反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C 2.1: triethylamine; magnesium chloride / acetonitrile / 0.25 h / -10 - 0 °C 2.2: 0.25 h 2.3: 1.5 h / Reflux 3.1: acetonitrile / 4 h / Reflux 4.1: AlCl3, aluminium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / -5 - 5 °C 4.2: 1 h / -5 - 20 °C View Scheme
参考文献
Haddach, Mustapha; Schwaebe, Michael K.; Michaux, Jerome; Nagasawa, Johnny; O'Brien, Sean E.; Whitten, Jeffrey P.; Pierre, Fabrice; Kerdoncuff, Pauline; Darjania, Levan; Stansfield, Ryan; Drygin, Denis; Anderes, Kenna; Proffitt, Chris; Bliesath, Josh; Siddiqui-Jain, Adam; Omori, May; Huser, Nanni; Rice, William G.; Ryckman, David M.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 7 p. 602 - 606