2-(2,3-环氧丙氧基)苯腈合成路线 （共 12 条）
参考文献
Boehringer Ingelheim GmbH
Patent: US3940489 A1, 1976 ;
反应条件
sodium hydroxide in water
T=50°C;
参考文献
Kopka, Klaus; Wagner, Stefan; Riemann, Burkhard; Law, Marilyn P; Puke, Carsten; Luthra, Sajinder K; Pike, Victor W; Wichter, Thomas; Schmitz, Wilhelm; Schober, Otmar; Schaefers, Michael
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3513 - 3527
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Mead Johnson and Company
Patent: US4234595 A1, 1980 ;
US 4234595 A
反应条件
sodium hydroxide in tetrahydrofuran
T=20 - 60°C; 0.666667 h;
参考文献
Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289
反应条件
1: piperidine / Heating
2: 1N aq. NaOH / tetrahydrofuran / 0.67 h / 20 - 60 °C
View Scheme
参考文献
Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289
参考文献
NPS Pharmaceuticals, Inc.; SmithKline Beecham, Corp.; SmithKline Beecham, PLC
Patent: US6022894 A1, 2000 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide; potassium carbonate
T=106°C; 0.283333 h;
参考文献
Pchelka, Beata K.; Loupy, Andre; Petit, Alain
Tetrahedron, 2006 , vol. 62, # 47 p. 10968 - 10979
参考文献
Slater; Howson; Swayne; Taylor; Reavill
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 345 - 351
反应条件
T=120 - 140°C; 0.5 h;
参考文献
Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289
反应条件
Resolution of racemate;
参考文献
Kong, Xu-Dong; Ma, Qian; Zhou, Jiahai; Zeng, Bu-Bing; Xu, Jian-He
Angewandte Chemie - International Edition, 2014 , vol. 53, # 26 p. 6641 - 6644
Angew. Chem., 2014 , p. 6759 - 6762,4
