1: N1'-DMTr-biotin methylester With sodium hydride in N,N-dimethyl-formamide; mineral oil
0.5 h; Inert atmosphereCooling with ice;
2: undec-10-enoic acid chloride With tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide; mineral oil
T=20°C; Cooling with iceInert atmosphere; regioselective reaction;
参考文献
Pehere, Ashok D.; Abell, Andrew D.
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9514 - 9518
diethyl ether; triethylamine
Erwaermen des Reaktionsprodukts mit wss.-aethanol Kalilauge;
参考文献
Hatt; Lamberton
Australian Journal of Chemistry, 1955 , vol. 8, p. 506,511
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Piekarski
J.Recherches Centre nation., 1957 , vol. 8, p. 197,229