1-三甲基硅烷-1-己炔合成路线 （共 85 条）
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; hexane / 0.5 h / 20 °C
1.3: tetrahydrofuran; hexane / 3 h / 20 °C
2.1: NaOH / methanol; tetrahydrofuran; H2O
3.1: LiHMDS / tetrahydrofuran / -78 °C
3.2: lithium tert-butyl peroxide / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C
3.3: 93 percent / tetrahydrofuran; toluene / 0.5 h / 0 °C
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; hexane / 0.5 h / 20 °C
1.3: tetrahydrofuran; hexane / 3 h / 20 °C
2.1: NaOH / methanol; tetrahydrofuran; H2O
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
1.1: n-BuLi / tetrahydrofuran; petroleum ether / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; petroleum ether / 0.5 h / 20 °C
1.3: tetrahydrofuran; petroleum ether / 20 °C
2.1: aq. NaOH / methanol; tetrahydrofuran
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
1.1: n-BuLi / tetrahydrofuran; petroleum ether / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; petroleum ether / 0.5 h / 20 °C
1.3: tetrahydrofuran; petroleum ether / 20 °C
2.1: aq. NaOH / methanol; tetrahydrofuran
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; hexane / 0.5 h / 20 °C
1.3: tetrahydrofuran; hexane / 3 h / 20 °C
2.1: NaOH / methanol; tetrahydrofuran; H2O
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
1.1: n-BuLi / tetrahydrofuran; petroleum ether / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; petroleum ether / 0.5 h / 20 °C
1.3: tetrahydrofuran; petroleum ether / 20 °C
2.1: aq. NaOH / methanol; tetrahydrofuran
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 0.25 h; Inert atmosphere;
参考文献
Chintareddy, Venkat Reddy; Wadhwa, Kuldeep; Verkade, John G.
Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4482 - 4488
反应条件
1.1: dicyclohexylborane / tetrahydrofuran / 0 - 20 °C
1.2: 82 percent / AcOH / tetrahydrofuran / 6 h / 20 °C
2.1: CH2Cl2 / 6 h / 20 °C
3.1: 84 percent / CH2Cl2 / 0.5 h / 0 °C
4.1: 80 percent / sodium hydroxide; aq. H2O2 / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Chuang, Tsung-Hsun; Fang, Jim-Min; Jiaang, Weir-Torn; Tsai, Yeun-Min
Journal of Organic Chemistry, 1996 , vol. 61, # 5 p. 1794 - 1805
反应条件
1: With zirconocene dichloride; magnesium in tetrahydrofuran
T=0 - 21°C; 5 h; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; water
regioselective reaction;
参考文献
D'yakonov; Timerkhanov; Tyumkina; Dzhemilev
Russian Chemical Bulletin, 2009 , vol. 58, # 12 p. 2456 - 2464
Izv. Akad. Nauk, Ser. Khim., 2009 , # 12 p. 2378 - 2385,8
反应条件
1: BuMgHlg (Hlg = Cl, Br) / Cp2ZrCl2 / diethyl ether / 2 h / 20 °C
2: H3O(1+)
View Scheme
参考文献
Luo, Qian; Wang, Chao; Gu, Li; Zhang, Wen-Xiong; Xi, Zhenfeng
Chemistry - An Asian Journal, 2010 , vol. 5, # 5 p. 1120 - 1128
