2-(Boc-氨基)吡啶合成路线 （共 33 条）
反应条件
in PEG-400 T=20°C; 0.25 h;
参考文献
Siddaiah; Basha; Padma Rao; Viplava Prasad; Suryachendra Rao
Chemistry Letters, 2010 , vol. 39, # 11 p. 1127 - 1129
反应条件
PMHS; palladium dihydroxide in ethanol T=20°C; 5 h;
参考文献
Chandrasekhar; Babu, B. Nagendra; Reddy, Ch. Raji
Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2057 - 2059
反应条件
1: 2-aminopyridine With sodium hexamethyldisilazane in tetrahydrofuran 0.583333 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=0 - 20°C;
参考文献
3M INNOVATIVE PROPERTIES COMPANY
Patent: WO2006/107851 A1, 2006 ;
Location in patent: Page/Page column 58 ;
反应条件
in dichloromethane T=0 - 20°C;
参考文献
NEUROGEN CORPORATION
Patent: WO2006/52546 A2, 2006 ;
Location in patent: Page/Page column 84 ;
反应条件
in tert-butyl alcohol T=20°C; 24 h;
参考文献
Niijima, Jun; Nakamoto, Kazutaka; Matsukura, Masayuki; Tanaka, Keigo; Yamamoto, Eiichi; Minamisono, Takuma
Patent: US2008/275244 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
in tert-butyl alcohol Ambient temperature;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
参考文献
Tanaka, Keigo
Patent: US2010/105737 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
n-butyllithium; dimethylsulfide; copper(I) bromide 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 to -60 deg C, 1 h, 3.) THF, hexane, 0 deg C, 2.5 h; Yield given. Multistep reaction;
参考文献
Greck, Christine; Bischoff, Laurent; Girard, Anne; Hajicek, Josef; Genet, Jean-Pierre
Bulletin de la Societe Chimique de France, 1994 , vol. 131, # 4 p. 429 - 433
反应条件
1: 95 percent / NaH / dimethylformamide / 1.5 h / 0 - 20 °C 2: 97 percent / TFA / CH2Cl2; H2O View Scheme
参考文献
Krein, Douglas M.; Lowary, Todd L.
Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4965 - 4967
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: -78 - -20 °C / Inert atmosphere 1.3: -78 - 20 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere 3.1: N-chloro-succinimide / acetonitrile / 2 h / Reflux; Inert atmosphere View Scheme
参考文献
Hou, Chuan-Jin; Guo, Wei-Lei; Liu, Xiao-Ning; Yang, Da-Wei
Heterocyclic Communications, 2011 , vol. 17, # 1-2 p. 21 - 23
