5-(4-氯苯基)噻吩-2-甲醛合成路线 （共 11 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate in 1,4-dioxane T=80°C; Suzuki reaction;
参考文献
Zhao, Lianyun; Zhang, Yingxin; Dai, Chaoyang; Guzi, Timothy; Wiswell, Derek; Seghezzi, Wolfgang; Parry, David; Fischmann, Thierry; Siddiqui, M. Arshad
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7216 - 7221
反应条件
1: 4-chlorophenyl-magnesium bromide With bismuth(III) chloride 2: 5-Bromothiophene-2-carboxaldehyde With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere; chemoselective reaction;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: 4-chloro-aniline With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 2: thiophene-2-carbaldehyde With CuCl2*2H2O in dimethyl sulfoxide T=15 - 25°C; Meerwein reaction;
参考文献
Obushak; Matiychuk; Lytvyn
Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 8 p. 936 - 940
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in toluene Heating;
参考文献
Johnson, Sherida L.; Jung, Dawoon; Forino, Martino; Chen, Ya; Satterthwait, Arnold; Rozanov, Dmitry V.; Strongin, Alex Y.; Pellecchia, Maurizio
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 27 - 30
反应条件
1.1: AlCl3 / CS2 / 2.5 h / 20 °C 2.1: dimethylformamide / 22 h / 5 °C 3.1: H2SO4 / methanol / 1 h / Heating 3.2: chloranil / benzene / 2 h / Heating 4.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: dimethylformamide / 22 h / 5 °C 2.1: H2SO4 / methanol / 1 h / Heating 2.2: chloranil / benzene / 2 h / Heating 3.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: H2SO4 / methanol / 1 h / Heating 1.2: chloranil / benzene / 2 h / Heating 2.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
trichlorophosphate in 1,2-dichloro-ethane Vilsmeier reaction; 17 h; Heating;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
sodium hydroxide; silver(l) oxide in water T=20 - 50°C;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 86 percent / NaOH; Ag2O / H2O / 20 - 50 °C
2: 86 percent / H2SO4 / toluene / 7 h / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
