2-氯-2,4,6-环庚三烯-1-酮合成路线 （共 41 条）
反应条件
1: 1.) benzene, Et2O, -78 deg C, 30 min, 2.) 0 deg C, overnight
2: 26 percent / SeO2 / tetrahydrofuran / 0.83 h / Heating
View Scheme
参考文献
Cavazza, Marino; Morganti, Gioia; Guerriero, Antonio; Pietra, Francesco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 2 p. 199 - 202
反应条件
1: 1.) t-BuOK / 1.) THF, RT, 0.5 h, 2.) THF, RT, 0.5 h
2: 88 percent / benzene / 24 h / Heating
View Scheme
参考文献
Wetzel, Arthur; Lewars, Errol G.; Zeller, Klaus-Peter
Synthesis, 1983 , # 11 p. 945 - 946
反应条件
1: NaOEt / ethanol
2: aq. KOH / ethanol / Heating
3: pyridine / 125 - 130 °C
View Scheme
参考文献
Nozoe,T. et al.
Bulletin of the Chemical Society of Japan, 1962 , vol. 35, # 7 p. 1179 - 1188
反应条件
1: NaN3 / dimethylsulfoxide
2: H2 / Pd-C / ethanol
View Scheme
参考文献
Hobson,J.D.; Malpass,J.R.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 1645 - 1648
反应条件
ethanol; sodium ethanolate
参考文献
Nozoe,T. et al.
Bulletin of the Chemical Society of Japan, 1962 , vol. 35, # 7 p. 1179 - 1188
Full Text Show Details
McDonald,R.N.; Richmond,J.M.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1689 - 1694
参考文献
Nozoe,T. et al.
Bulletin of the Chemical Society of Japan, 1962 , vol. 35, # 7 p. 1179 - 1188
参考文献
Nozoe,T. et al.
Bulletin of the Chemical Society of Japan, 1962 , vol. 35, # 7 p. 1179 - 1188
反应条件
1: NaOEt / ethanol
2: HCl, isopentyl nitrite / benzene
3: (i) (saponification), (ii) (thermolysis)
4: CCl4
5: (i) aq. KOH, EtOH, (ii) /BRN= 102415/, Et2O
View Scheme
参考文献
McDonald,R.N.; Richmond,J.M.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1689 - 1694
反应条件
1: NaOEt / ethanol
2: HCl, isopentyl nitrite / benzene
3: (i) (saponification), (ii) (thermolysis)
4: CCl4
5: (i) aq. KOH, EtOH, (ii) /BRN= 102415/, Et2O
6: NaH / dimethylformamide
View Scheme
参考文献
McDonald,R.N.; Richmond,J.M.
Journal of Organic Chemistry, 1975 , vol. 40, p. 1689 - 1694
反应条件
bis-triphenylphosphine-palladium(II) chloride; caesium carbonate in tetrahydrofuran; water
T=75°C; Suzuki Coupling; 16 h; Inert atmosphere;
参考文献
Ononye, Sophia N.; Vanheyst, Michael D.; Oblak, E. Zachary; Zhou, Wangda; Ammar, Mohamed; Anderson, Amy C.; Wright, Dennis L.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 8 p. 757 - 761
