3H-螺[2-苯并呋喃-1,4'-哌啶]合成路线 （共 9 条）
反应条件
1: With nickel in ethanol T=20°C; 2: With hydrogen; palladium 10 on activated carbon in ethanol T=40°C; P=3750.38 Torr; 43 h;
参考文献
Bissantz, Caterina; Goetschi, Erwin; Grundschober, Christophe; Masciadri, Raffaello; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick
Patent: US2008/171759 A1, 2008 ;
Location in patent: Page/Page column 20 ;
US 20080171759 A1
反应条件
sodium hydroxide in ethanol 20 h; Heating;
参考文献
Kubota, Hirokazu; Fujii, Masahiro; Ikeda, Ken; Takeuchi, Makoto; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 351 - 354
反应条件
hydrogen; palladium on activated charcoal in ethanol 20 h;
参考文献
Marxer; Rodriguez; McKenna; Tsai
Journal of Organic Chemistry, 1975 , vol. 40, # 10 p. 1427 - 1433
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; recombinant cytochrome P450 1A2; NADPH in water T=37°C; pH=7.4; 0.5 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Grosse Maestrup, Eva; Wiese, Christian; Schepmann, Dirk; Hiller, Achim; Fischer, Steffen; Scheunemann, Matthias; Brust, Peter; Wuensch, Bernhard
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3630 - 3641
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; recombinant cytochrome P450 3A4; NADPH in water T=37°C; pH=7.4; 0.5 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Grosse Maestrup, Eva; Wiese, Christian; Schepmann, Dirk; Hiller, Achim; Fischer, Steffen; Scheunemann, Matthias; Brust, Peter; Wuensch, Bernhard
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3630 - 3641
反应条件
1: 81 percent / TsCl, pyridine / CH2Cl2 / 58 h / Ambient temperature 2: 89 percent / 5N NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Kubota, Hirokazu; Fujii, Masahiro; Ikeda, Ken; Takeuchi, Makoto; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 351 - 354
反应条件
1: 1.) n-BuLi / 1.) n-hexane, THF, Et2O, -78 deg C, 1 h, 2.) n-hexane, THF, Et2O, RT, 16 h 2: 81 percent / TsCl, pyridine / CH2Cl2 / 58 h / Ambient temperature 3: 89 percent / 5N NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Kubota, Hirokazu; Fujii, Masahiro; Ikeda, Ken; Takeuchi, Makoto; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 351 - 354
反应条件
1: 1.) n-BuLi / 1.) n-hexane, THF, Et2O, -78 deg C, 1 h, 2.) n-hexane, THF, Et2O, RT, 16 h 2: 81 percent / TsCl, pyridine / CH2Cl2 / 58 h / Ambient temperature 3: 89 percent / 5N NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Kubota, Hirokazu; Fujii, Masahiro; Ikeda, Ken; Takeuchi, Makoto; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 351 - 354
反应条件
potassium carbonate; isobutyl methylketone 16 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 11 p. 1998 - 2008
